Study summary

The purpose of this study is to evaluate the tolerability and safety profile of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab in participants with locally advanced (unresectable) or metastatic solid tumors; characterize the pharmacokinetic profile of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab and determine the recommended Phase 2 dose (RP2D) of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab. This study will also evaluate the antitumor effect of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab.

Additional Study Details

Phase
Phase 1
Product
  • ASP1948
  • nivolumab
  • pembrolizumab
  • Type
    Interventional
    Masking
    None (Open Label)
    Enrollment number
    190
    Show Additional Study Details

    Study documents

    Scientific Results Summary
    Available Language(s): English
    Plain Language Summary
    Available Language(s): English

    Get more information

    Would you like more information about clinical trial sites that are recruiting participants for A Study of ASP1948, Targeting an Immune Modulatory Receptor as a Single Agent and in Combination With a PD-l Inhibitor (Nivolumab or Pembrolizumab) in Subjects With Advanced Solid Tumors? Contact us by filling out your information to the right and we’ll respond to you.

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    • Algeria
    • Argentina
    • Armenia
    • Australia
    • Austria
    • Belarus
    • Belgium
    • Bosnia And Herzegovina
    • Brazil
    • Bulgaria
    • Canada
    • Chile
    • China
    • Colombia
    • Croatia
    • Czech Republic
    • Denmark
    • Dominican Republic
    • Egypt
    • Estonia
    • Finland
    • Former Serbia and Montenegro
    • France
    • Georgia
    • Germany
    • Greece
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      Locations

      Contact Us
      Contact Us
      Completed
      Norton Cancer Institute
      Louisville, KY, United States, 40202
      Completed
      Site TW88602
      Taipei, Taiwan, Province of China
      Completed
      Oncology Hematology West P.C. dba Nebraska Cancer Specialists
      Omaha, NE, United States, 68310
      Completed
      Site KR82002
      Seoul, Republic of Korea
      Completed
      Washington University
      St. Louis, MO, United States, 63110
      Withdrawn
      University of Chicago
      Chicago, IL, United States, 60637
      Completed
      Site KR82005
      Seoul, Republic of Korea
      Completed
      Mary Crowley Cancer Research Center
      Dallas, TX, United States, 75230
      Completed
      Site KR82004
      Seoul, Republic of Korea
      Completed
      Comprehensive Cancer Centers of Nevada
      Las Vegas, NV, United States, 89169
      Withdrawn
      University of Tennessee Medical Center
      Knoxville, TN, United States, 37920
      Withdrawn
      Montefiore Medical Center
      Bronx, NY, United States, 10461
      Completed
      Virginia Cancer Care Specialist, PC
      Fairfax, VA, United States, 22031
      Completed
      Henry-Joyce Cancer Center
      Nashville, TN, United States, 37232
      Withdrawn
      Site CA15001
      Toronto, Canada
      Withdrawn
      Memorial Sloan Kettering Cancer Center
      New York, NY, United States, 10065
      Completed
      Cancer Center at Greater Baltimore Medical
      Baltimore, MD, United States, 21153
      Completed
      University of Washington-Seattle Cancer Care Alliance
      Seattle, WA, United States, 98109
      Completed
      Icahn School of Medicine at Mount Sinai
      New York, NY, United States, 10029
      Completed
      Site KR82001
      Seoul, Republic of Korea
      Completed
      Site CA15004
      Montreal, Canada
      Completed
      University of Oklahoma
      Oklahoma City, OK, United States, 73104
      Completed
      University of Michigan Comprehensive Cancer Center
      Ann Arbor, MI, United States, 48109
      Completed
      Sarah Cannon Research Institute – SCRI
      Nashville, TN, United States, 37203
      Withdrawn
      Froedtert & The medical college of Wisconsin
      Milwaukee, WI, United States, 53226
      Withdrawn
      Oregon Health and Science University
      Portland, OREGON, United States, 97239
      Withdrawn
      The Ohio State University James Cancer Hospital and Solove Research Institute
      Columbus, OH, United States, 43210
      Completed
      Site KR82006
      Seoul, Republic of Korea
      Completed
      Site KR82003
      Seoul, Republic of Korea
      Completed
      Yale Center for Clinical Investigation
      New Haven, CT, United States, 06520-8028
      Withdrawn
      Augusta University
      Augusta, Georgia, United States, 30912
      Completed
      UPMC- Hillman Cancer Center
      Pittsburgh, PA, United States, 15232
      Completed
      Site KR82007
      Seoul, Republic of Korea
      Completed
      University of South Carolina
      Charleston, SC, United States, 29425
      Withdrawn
      Dartmouth Hitchcock Med Center
      Lebanon, New Hampshire, United States, 03756
      Completed
      South Texas Accelerated Research Therapeutics
      San Antonio, TX, United States, 78229
      Completed
      Site CA15002
      Edmonton, Canada
      Withdrawn
      Women And Infants
      Providence, RI, United States, 02905
      Withdrawn
      Site ES34001
      Avila, Spain
      Completed
      Site ES34003
      Cataluna, Spain
      Completed
      Site ES34004
      Cataluna, Spain
      Withdrawn
      Site ES34005
      Valencia, Spain
      Completed
      Site ES34007
      Madrid, Spain
      Withdrawn
      Site ES34009
      Madrid, Spain
      Completed
      Site ES34012
      Madrid, Spain
      Withdrawn
      Site GB44001
      Glasgow, United Kingdom
      Completed
      Site TW88601
      Taipei, Taiwan, Province of China
      Completed
      Site ES34010
      Barcelona, Spain
      Completed
      Site JP81001
      Tokyo, Japan
      Completed
      Site JP81002
      Chiba, Japan
      Completed
      Site IT39006
      Modena, Italy
      Completed
      Site IT39008
      Milano, Italy
      Withdrawn
      Site IT39003
      Meldola, Italy
      Completed
      Site ES34002
      Barcelona, Spain
      Withdrawn
      Huntsman Cancer Institute
      Salt Lake City, Utah, United States, 84112
      Completed
      Site ES34006
      Barcelona, Spain
      Completed
      Site ES34014
      Barcelona, Spain
      Withdrawn
      Site CA15006
      Toronto, Canada
      Withdrawn
      Site IT39001
      Monza, Italy
      Withdrawn
      Site IT39005
      Milano, Italy
      Withdrawn
      Site IT39007
      Milano, Italy
      Completed
      Site PT35104
      Porto, Portugal
      Withdrawn
      Site PT35105
      Braga, Portugal
      Withdrawn
      Site GB44003
      Sheffield, United Kingdom
      Withdrawn
      Site GB44004
      Newcastle upon Tyne, United Kingdom
      Completed
      Site GB44006
      Manchester, United Kingdom
      Withdrawn
      Mayo clinic
      Phoenix, AZ, United States, 85259
      Withdrawn
      Site TW88603
      Tainan, Taiwan, Province of China
      Withdrawn
      Henry Ford Health System
      Detroit, MI, United States, 48202

      Frequently Asked Questions

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      In cancer clinical trials, a placebo is only used if there is no other treatment for that type of cancer. This helps compare an investigational treatment to the placebo. Placebos are rarely used in cancer trials because the best available treatment, called the “standard of care”, is usually given instead.

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