Study summary

The primary purpose of this study is to determine the antitumor activity of enfortumab vedotin as measured by confirmed objective response rate (ORR) per RECIST v1.1.

This study will also assess other measures of antitumor activity; overall survival (OS); as well as the safety and tolerability of enfortumab vedotin for cohorts 1 to 8 and enfortumab vedotin + pembrolizumab in cohort 9.

Additional Study Details

Phase
Phase 2
Product
  • enfortumab vedotin
  • pembrolizumab
  • Type
    Interventional
    Masking
    None (Open Label)
    Enrollment number
    329
    Show Additional Study Details

    Get more information

    Would you like more information about clinical trial sites that are recruiting participants for A Study to Evaluate Enfortumab Vedotin in Subjects with Locally Advanced or Metastatic Malignant Solid Tumors (EV-202)? Contact us by filling out your information to the right and we’ll respond to you.

    • A patient
    • A caregiver
    • A parent
    • A healthcare provider
    • A patient advocate
    • Algeria
    • Argentina
    • Armenia
    • Australia
    • Austria
    • Belarus
    • Belgium
    • Bosnia And Herzegovina
    • Brazil
    • Bulgaria
    • Canada
    • Chile
    • China
    • Colombia
    • Croatia
    • Czech Republic
    • Denmark
    • Dominican Republic
    • Egypt
    • Estonia
    • Finland
    • Former Serbia and Montenegro
    • France
    • Georgia
    • Germany
    • Greece
    • Guatemala
    • Hong Kong
    • Hungary
    • Iceland
    • India
    • Indonesia
    • Ireland
    • Israel
    • Italy
    • Japan
    • Jordan
    • Kazakhstan
    • Latvia
    • Lebanon
    • Lithuania
    • Macedonia
    • Malaysia
    • Mexico
    • Montenegro
    • Morocco
    • Netherlands
    • New Zealand
    • Norway
    • Panama
    • Peru
    • Philippines
    • Poland
    • Portugal
    • Puerto Rico
    • Republic of Korea
    • Republic of Moldova
    • Romania
    • Russian Federation
    • Saudi Arabia
    • Serbia
    • Singapore
    • Slovakia
    • Slovenia
    • South Africa
    • Spain
    • Sweden
    • Switzerland
    • Taiwan, Province of China
    • Thailand
    • Turkey
    • Ukraine
    • United Kingdom
    • United States
    • Vietnam

    By clicking ["Continue/Submit"], you agree that Astellas may contact you by email with information to help you connect with clinical trial sites. While we can connect you to clinical trial sites, we cannot answer questions about any investigational therapy through email. Your consent to receiving emails is not a requirement to participate in a clinical trial or study. For more information, including how to unsubscribe at any time, see our Privacy Notice & Cookies Policy.

      Locations

      Contact Us
      Contact Us
      Active, not recruiting
      Site JP81002
      Koto, Tokyo, Japan
      Completed
      Gettysburg Cancer Center
      Gettysburg, PA, United States, 17375
      Active, not recruiting
      Seattle Cancer Care Alliance
      Seattle, WA, United States, 98109
      Active, not recruiting
      Site JP81004
      Nagoya, Aichi, Japan
      Active, not recruiting
      Site JP81003
      Chuo, Tokyo, Japan
      Active, not recruiting
      New York University Langone Health
      New York, NY, United States, 10016
      Completed
      Piedmont Hospital
      Atlanta, GA, United States, 30318
      Active, not recruiting
      Site JP81001
      Kashiwa, Chiba, Japan
      Active, not recruiting
      Mary Crowley Research Center
      Dallas, TX, United States, 75230
      Active, not recruiting
      Arizona Oncology
      Tucson, AZ, United States, 85711
      Active, not recruiting
      University of Kansas
      Fairway, KS, United States, 66205
      Active, not recruiting
      Site JP81006
      Nagaizumi, Shizuoka, Japan
      Active, not recruiting
      University of Colorado
      Aurora, CO, United States, 80045
      Active, not recruiting
      Comprehensive Cancer Centers of Nevada
      Las Vegas, NV, United States, 89169
      Completed
      Indiana University Cancer Center
      Indianapolis, IN, United States, 46202
      Withdrawn
      University of Southern California
      Los Angeles, CA, United States, 90033
      Withdrawn
      Washington University in St. Louis
      St. Louis, MO, United States, 63110
      Active, not recruiting
      University of Michigan
      Ann Arbor, MI, United States, 48109
      Active, not recruiting
      Florida Cancer Specialists
      Tallahassee, FL, United States, 32308
      Completed
      Northside Hospital
      Atlanta, GA, United States, 30342
      Active, not recruiting
      Northwestern University Medical Center
      Chicago, IL, United States, 60611
      Active, not recruiting
      Ohio State University
      Columbus, OH, United States, 43210
      Active, not recruiting
      Cleveland Clinic
      Cleveland, OH, United States, 44195
      Completed
      Nebraska Methodist Hospital
      Omaha, NE, United States, 68114
      Active, not recruiting
      Wisconsin Carbone Cancer Center
      Madison, WI, United States, 53792
      Active, not recruiting
      Florida Cancer Specialists
      West Palm Beach, FL, United States, 33401
      Active, not recruiting
      Florida Cancer Specialists
      Fort Myers, FL, United States, 33901
      Active, not recruiting
      Site JP81005
      Chuo-ku, Osaka, Japan
      Active, not recruiting
      Henry Ford Hospital
      Detroit, MI, United States, 48202
      Active, not recruiting
      Rutgers Cancer Institute
      New Brunswick, New Jersey, United States, 08901
      Active, not recruiting
      University of Chicago
      Chicago, IL, United States, 60637
      Active, not recruiting
      Dana-Farber Cancer Institute
      Boston, MA, United States, 02215
      Active, not recruiting
      University of Texas
      Houston, TX, United States, 77030
      Withdrawn
      Ochsner Medical Center
      New Orleans, LA, United States, 70121
      Withdrawn
      Site CA15001
      Hamilton, ON, Canada, L8V 5C2
      Active, not recruiting
      Site CA15003
      Ottawa, ON, Canada, K1H 8L6
      Active, not recruiting
      University of Minnesota Cancer Center
      Minneapolis, MN, United States, 55455
      Withdrawn
      Dartmouth-Hitchcock Norris Cotton Cancer Center
      Lebanon, NH, United States, 03765
      Completed
      Sarah Cannon Research Institute
      Nashville, TN, United States, 37203
      Withdrawn
      University of Cincinnati
      Cincinnati, OH, United States, 45219
      Active, not recruiting
      Site JP81007
      Osaka-Sayama, Osaka, Japan
      Active, not recruiting
      Memorial Sloan Kettering Cancer Center
      New York, NY, United States, 10022
      Withdrawn
      Site CA15002
      Vancouver, BC, Canada, V5Z 4E6
      Withdrawn
      Providence St. Joseph Medical Center
      Burbank, CA, United States, 91505
      Withdrawn
      Site JP81009
      Shinjuku-ku, Tokyo, Japan
      Completed
      Site JP81010
      Okayama, Okayama, Japan
      Active, not recruiting
      Site JP81011
      Kitaadachi-Gun, Saitama, Japan
      Withdrawn
      University of Nebraska
      Omaha, NE, United States, 68198
      Withdrawn
      Site CA15005
      Montreal, Quebec, Canada, H3T 1E2
      Active, not recruiting
      University of California - San Francisco
      San Francisco, CA, United States, 94158
      Withdrawn
      Beth Israel Deaconess Medical Center
      Boston, MA, United States, 02215

      Frequently Asked Questions

      Are clinical trials only for people with advanced cancer?

      While some clinical trials may focus on more advanced cancers, many trials are open to patients at various stages of their cancer. Each study has rules about who can take part. For example, only patients in a certain age group or those who have a certain type of tumor may be able to join.

      Will I have to stop my current treatment to participate in a clinical trial?

      Sometimes researchers want participants to keep taking their current treatments during a clinical trial. Other times, you may need to stop your current treatments for a while. If the investigational treatment doesn't work, you can usually go back to your original treatment plan.

      Should I be worried about getting a placebo?

      In cancer clinical trials, a placebo is only used if there is no other treatment for that type of cancer. This helps compare an investigational treatment to the placebo. Placebos are rarely used in cancer trials because the best available treatment, called the “standard of care”, is usually given instead.

      Do I need a referral from my doctor to take part in a study?

      Your doctor may not know about all the opportunities for clinical trials that are available to you. Talk to your doctor or other medical provider about clinical trial information that you find. They can help you decide if a clinical trial is right for you. If you do not find any options on this website, we recommend you visit an online public registry website like clinicaltrials.gov to see a wide variety of available clinical trials.

      Explore More

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      Why Participate in a Clinical Trial?