Study summary

The purpose of this study was to determine the efficacy and safety of oral enzalutamide compared to bicalutamide in castrate men with metastatic prostate cancer who have progressed while on Luteinizing Hormone Receptor Hormone (LHRH) agonist/antagonist or after receiving a bilateral orchiectomy.

Additional Study Details

Phase
2
Product
N/A
Product
enzalutamide
bicalutamide
Type
Interventional
Masking
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Enrollment number
375
Show Additional Study Details

Study documents

Scientific Results Summary
Available Language(s): English
Scientific Results Summary 2
Available Language(s): English
Plain Language Summary
Available Language(s): English

Get more information

Would you like more information about clinical trial sites that are recruiting participants for A Study of Enzalutamide versus Bicalutamide in Castrate Men with Metastatic Prostate Cancer? Contact us by filling out your information to the right and we’ll respond to you.

  • A caregiver
  • A healthcare provider
  • A parent
  • A patient
  • A patient advocate
  • Algeria
  • Argentina
  • Armenia
  • Australia
  • Austria
  • Belarus
  • Belgium
  • Bosnia And Herzegovina
  • Brazil
  • Bulgaria
  • Canada
  • Chile
  • China
  • Colombia
  • Croatia
  • Czech Republic
  • Denmark
  • Dominican Republic
  • Egypt
  • Estonia
  • Finland
  • Former Serbia and Montenegro
  • France
  • Georgia
  • Germany
  • Greece
  • Guatemala
  • Hong Kong
  • Hungary
  • Iceland
  • India
  • Indonesia
  • Ireland
  • Israel
  • Italy
  • Japan
  • Jordan
  • Kazakhstan
  • Latvia
  • Lebanon
  • Lithuania
  • Macedonia
  • Malaysia
  • Mexico
  • Montenegro
  • Morocco
  • Netherlands
  • New Zealand
  • Norway
  • Panama
  • Peru
  • Philippines
  • Poland
  • Portugal
  • Puerto Rico
  • Republic of Korea
  • Republic of Moldova
  • Romania
  • Russian Federation
  • Saudi Arabia
  • Serbia
  • Singapore
  • Slovakia
  • Slovenia
  • South Africa
  • Spain
  • Sweden
  • Switzerland
  • Taiwan, Province of China
  • Thailand
  • Turkey
  • Ukraine
  • United Kingdom
  • United States
  • Vietnam

By clicking ["Continue/Submit"], you agree that Astellas may contact you by email with information to help you connect with clinical trial sites. While we can connect you to clinical trial sites, we cannot answer questions about any investigational therapy through email. Your consent to receiving emails is not a requirement to participate in a clinical trial or study. For more information, including how to unsubscribe at any time, see our Privacy Notice & Cookies Policy.

    Locations

    Contact Us
    Contact Us
    Withdrawn
    Site FR3006
    Saint Etienne Cedex 2, France, 42013
    Completed
    Site DK3356
    Aarhus, Denmark, 8200
    Completed
    Site GB3245
    Northwood, Middlesex, United Kingdom, HA6 2RN
    Completed
    Site US2945
    Middlebury, CT, United States, 06762
    Completed
    Site CA3084
    Toronto, ON, Canada, M5G 2M9
    Withdrawn
    Site US2640
    Los Angeles, CA, United States, 90048
    Completed
    Site US3025
    Poughkeepsie, NY, United States, 12601
    Completed
    Site GB3028
    Cardiff, Wales, United Kingdom, CF14 4XW
    Completed
    Site BE3289
    Liege, Belgium
    Completed
    Site US1598
    Bala Cynwyd, PA, United States, 19004
    Withdrawn
    Site US3197
    Raleigh, NC, United States, 27607
    Completed
    Site US2014
    Melrose Park, IL, United States, 60160
    Completed
    Site GB3030
    London, UK, United Kingdom, SW17 0QT
    Completed
    Site US1580
    Burien, WA, United States, 98166
    Completed
    Site GB3166
    Glasgow, United Kingdom, G12 0YN
    Completed
    Site DE2989
    Aachen, Germany, 51074
    Completed
    Site CA166
    Toronto, ON, Canada, M4N 3M5
    Completed
    Site GB2702
    Cambridge, United Kingdom, CB2 0QQ
    Completed
    Site BE3015
    Brussels, Belgium, 1090
    Completed
    Site DE2988
    Wuppertal, Germany, 42103
    Completed
    Site US2185
    Columbus, OH, United States, 43221
    Completed
    Site US62
    Kansas City, KS, United States, 66160-7233
    Withdrawn
    Site BE3017
    Antwerp, Belgium, 2030
    Completed
    Site DE2993
    Bonn, Germany, 53105
    Completed
    Site US44
    Cincinnati, OH, United States, 45267
    Completed
    Site DE3287
    Bergisch Gladbach, Germany, D-51465
    Completed
    Site CA3242
    Abbotsford, BC, Canada, V2S 3N5
    Completed
    Site US892
    Grand Rapids, MI, United States, 49546
    Completed
    Site DE3270
    Hannover, Germany, 30625
    Completed
    Site GB2624
    Manchester, United Kingdom, M20 4BX
    Completed
    Site DE4000
    Nuertingen, Baden-Wuerttemberg, Germany, 72622
    Withdrawn
    Site US3115
    Fort Myers, FL, United States, 33908
    Completed
    Site GB3029
    Bristol, UK, United Kingdom, BS2 8HW
    Completed
    Site US1838
    West Des Moines, IA, United States, 50266
    Completed
    Site US3182
    Bethesda, MD, United States, 20889-5600
    Completed
    Site US2977
    Highland, CA, United States, 92346
    Completed
    Site DK3354
    Aalborg, Denmark, 9000
    Completed
    Site CA170
    Montreal, QC, Canada, H3G 1A4
    Completed
    Site CA2984
    Granby, QC, Canada, J2G 8Z9
    Completed
    Site DE2994
    Bonn, Germany, 53117
    Completed
    Site BE1322
    Gent, Belgium, 9000
    Completed
    Site FR3003
    Poitiers Cedex, France, 86000
    Completed
    Site RO3039
    Bucharest, RO, Romania, 050659
    Completed
    Site CA3104
    Calgary, AB, Canada, T2V 1P9
    Completed
    Site BE3013
    Turnhout, Belgium, 2300
    Completed
    Site US1675
    Rochester, NY, United States, 14642
    Completed
    Site RO3035
    Bucharest, Romania, 041345
    Withdrawn
    Site US1684
    New York City, NY, United States, 10016
    Completed
    Site US20
    Minneapolis, MN, United States, 55455
    Completed
    Site US1709
    Wenatchee, WA, United States, 98801
    Withdrawn
    Site US3634
    Greenbelt, MD, United States, 20770
    Completed
    Site US3078
    Billings, MT, United States, 59101
    Withdrawn
    Site US3077
    Gainesville, FL, United States, 32608
    Completed
    Site FR3000
    Rennes Cedex, France, 35033
    Withdrawn
    Site US3629
    Tucson, AZ, United States, 85741
    Completed
    Site US464
    Houston, TX, United States, 77030
    Completed
    Site US1527
    Anchorage, AK, United States, 99503
    Completed
    Site US3026
    Tucson, AZ, United States, 85715
    Completed
    Site US81
    Chapel Hill, NC, United States, 27599
    Completed
    Site US51
    Milwaukee, WI, United States, 53226
    Completed
    Site GB3027
    London, UK, United Kingdom, SE19RT
    Withdrawn
    Site CA2973
    Montreal, QC, Canada, H2Z 1N2
    Completed
    Site CA2646
    Kingston, ON, Canada, K7L 2V7
    Completed
    Site GB3290
    Preston, United Kingdom, PR2 9HT
    Completed
    Site US2104
    Greensboro, NC, United States, 27403
    Completed
    Site US2934
    Staten Island, NY, United States, 10304
    Completed
    Site US1657
    Nashville, TN, United States, 37209
    Completed
    Site US1934
    Homewood, AL, United States, 35209
    Completed
    Site US2926
    Myrtle Beach, SC, United States, 29572
    Withdrawn
    Site US2969
    Greenbelt, MD, United States, 20770
    Completed
    Site GB3355
    Merseyside, United Kingdom, CH63 4JY
    Completed
    Site US1653
    Virginia Beach, VA, United States, 23462
    Completed
    Site US2975
    Ann Arbor, MI, United States, 48109
    Completed
    Site FR3009
    Lille, France, 59037
    Completed
    Site US2027
    Jeffersonville, IN, United States, 47130
    Withdrawn
    Site US1649
    Marietta, GA, United States, 30060
    Completed
    Site FR3007
    Rouen, France, 76031
    Completed
    Site GB3244
    Belfast, United Kingdom, BT9 7AB
    Completed
    Site US2968
    Lawrenceville, NJ, United States, 08648
    Completed
    Site FR1091
    Creteil, France, 94010
    Completed
    Site RO3042
    Bucharest, RO, Romania, 022328
    Completed
    Site BE3018
    Kortrijk, Belgium, 8500
    Completed
    Site DK1857
    Copenhagen, Denmark, 2200
    Completed
    Site DE2990
    Hamburg, Hamburg, Germany, 22081
    Withdrawn
    Site US2180
    Fort Wayne, IN, United States, 46825
    Completed
    Site US2935
    Denver, CO, United States, 80211
    Completed
    Site US1680
    Lancaster, PA, United States, 17604
    Completed
    Site US2976
    Baltimore, MD, United States, 21201
    Completed
    Site US2978
    San Antonio, TX, United States, 78229
    Completed
    Site DE3286
    Waldshut-Tiengen, Germany, 29761
    Completed
    Site GB1862
    Leicher, United Kingdom, LE5 4PW
    Completed
    Site FR3002
    Paris Cedex 10, France, 75020
    Completed
    Site DK1263
    Herlev, Denmark, 2730
    Completed
    Site DE2995
    Bonn, Germany, 53111
    Completed
    Site US2067
    Springfield, IL, United States, 62703
    Completed
    Site US3630
    San Diego, CA, United States, 92123
    Completed
    Site DE2992
    Reutlingen, Germany, 72764
    Completed
    Site BE3288
    Leuven, Belgium, 3000
    Completed
    Site GB3163
    London, United Kingdom, NW1 2PG
    Completed
    Site FR3005
    Suresnes Cedex, France, 92151
    Completed
    Site FR442
    Lyon Cedex 3, France, 69437

    Frequently Asked Questions

    Are clinical trials only for people with advanced cancer?

    While some clinical trials may focus on more advanced cancers, many trials are open to patients at various stages of their cancer. Each study has rules about who can take part. For example, only patients in a certain age group or those who have a certain type of tumor may be able to join.

    Will I have to stop my current treatment to participate in a clinical trial?

    Sometimes researchers want participants to keep taking their current treatments during a clinical trial. Other times, you may need to stop your current treatments for a while. If the investigational treatment doesn't work, you can usually go back to your original treatment plan.

    Should I be worried about getting a placebo?

    In cancer clinical trials, a placebo is only used if there is no other treatment for that type of cancer. This helps compare an investigational treatment to the placebo. Placebos are rarely used in cancer trials because the best available treatment, called the “standard of care”, is usually given instead.

    Do I need a referral from my doctor to take part in a study?

    Your doctor may not know about all the opportunities for clinical trials that are available to you. Talk to your doctor or other medical provider about clinical trial information that you find. They can help you decide if a clinical trial is right for you. If you do not find any options on this website, we recommend you visit an online public registry website like clinicaltrials.gov to see a wide variety of available clinical trials.

    Explore More

    1

    What are clinical trials?

    2

    Why are Clinical Trials Important?

    3

    Why Participate in a Clinical Trial?