Study summary

The purpose of this study was to determine the efficacy and safety of oral enzalutamide compared to bicalutamide in castrate men with metastatic prostate cancer who have progressed while on Luteinizing Hormone Receptor Hormone (LHRH) agonist/antagonist or after receiving a bilateral orchiectomy.

Additional Study Details

Phase
2
Product
  • enzalutamide
  • bicalutamide
  • Type
    Interventional
    Masking
    Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
    Enrollment number
    375
    Show Additional Study Details

    Study documents

    Scientific Results Summary
    Available Language(s): English
    Scientific Results Summary 2
    Available Language(s): English
    Plain Language Summary
    Available Language(s): English

    Get more information

    Would you like more information about clinical trial sites that are recruiting participants for A Study of Enzalutamide versus Bicalutamide in Castrate Men with Metastatic Prostate Cancer? Contact us by filling out your information to the right and we’ll respond to you.

    • A caregiver
    • A healthcare provider
    • A parent
    • A patient
    • A patient advocate
    • Algeria
    • Argentina
    • Armenia
    • Australia
    • Austria
    • Belarus
    • Belgium
    • Bosnia And Herzegovina
    • Brazil
    • Bulgaria
    • Canada
    • Chile
    • China
    • Colombia
    • Croatia
    • Czech Republic
    • Denmark
    • Dominican Republic
    • Egypt
    • Estonia
    • Finland
    • Former Serbia and Montenegro
    • France
    • Georgia
    • Germany
    • Greece
    • Guatemala
    • Hong Kong
    • Hungary
    • Iceland
    • India
    • Indonesia
    • Ireland
    • Israel
    • Italy
    • Japan
    • Jordan
    • Kazakhstan
    • Latvia
    • Lebanon
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    • Macedonia
    • Malaysia
    • Mexico
    • Montenegro
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    • South Africa
    • Spain
    • Sweden
    • Switzerland
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    • Thailand
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    • Ukraine
    • United Kingdom
    • United States
    • Vietnam

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      Locations

      Contact Us
      Contact Us
      Withdrawn
      Site FR3006
      Saint Etienne Cedex 2, France, 42013
      Completed
      Site DK3356
      Aarhus, Denmark, 8200
      Completed
      Site GB3245
      Northwood, Middlesex, United Kingdom, HA6 2RN
      Completed
      Site US2945
      Middlebury, CT, United States, 06762
      Completed
      Site CA3084
      Toronto, ON, Canada, M5G 2M9
      Withdrawn
      Site US2640
      Los Angeles, CA, United States, 90048
      Completed
      Site US3025
      Poughkeepsie, NY, United States, 12601
      Completed
      Site GB3028
      Cardiff, Wales, United Kingdom, CF14 4XW
      Completed
      Site BE3289
      Liege, Belgium
      Completed
      Site US1598
      Bala Cynwyd, PA, United States, 19004
      Withdrawn
      Site US3197
      Raleigh, NC, United States, 27607
      Completed
      Site US2014
      Melrose Park, IL, United States, 60160
      Completed
      Site GB3030
      London, UK, United Kingdom, SW17 0QT
      Completed
      Site US1580
      Burien, WA, United States, 98166
      Completed
      Site GB3166
      Glasgow, United Kingdom, G12 0YN
      Completed
      Site DE2989
      Aachen, Germany, 51074
      Completed
      Site CA166
      Toronto, ON, Canada, M4N 3M5
      Completed
      Site GB2702
      Cambridge, United Kingdom, CB2 0QQ
      Completed
      Site BE3015
      Brussels, Belgium, 1090
      Completed
      Site DE2988
      Wuppertal, Germany, 42103
      Completed
      Site US2185
      Columbus, OH, United States, 43221
      Completed
      Site US62
      Kansas City, KS, United States, 66160-7233
      Withdrawn
      Site BE3017
      Antwerp, Belgium, 2030
      Completed
      Site DE2993
      Bonn, Germany, 53105
      Completed
      Site US44
      Cincinnati, OH, United States, 45267
      Completed
      Site DE3287
      Bergisch Gladbach, Germany, D-51465
      Completed
      Site CA3242
      Abbotsford, BC, Canada, V2S 3N5
      Completed
      Site US892
      Grand Rapids, MI, United States, 49546
      Completed
      Site DE3270
      Hannover, Germany, 30625
      Completed
      Site GB2624
      Manchester, United Kingdom, M20 4BX
      Completed
      Site DE4000
      Nuertingen, Baden-Wuerttemberg, Germany, 72622
      Withdrawn
      Site US3115
      Fort Myers, FL, United States, 33908
      Completed
      Site GB3029
      Bristol, UK, United Kingdom, BS2 8HW
      Completed
      Site US1838
      West Des Moines, IA, United States, 50266
      Completed
      Site US3182
      Bethesda, MD, United States, 20889-5600
      Completed
      Site US2977
      Highland, CA, United States, 92346
      Completed
      Site DK3354
      Aalborg, Denmark, 9000
      Completed
      Site CA170
      Montreal, QC, Canada, H3G 1A4
      Completed
      Site CA2984
      Granby, QC, Canada, J2G 8Z9
      Completed
      Site DE2994
      Bonn, Germany, 53117
      Completed
      Site BE1322
      Gent, Belgium, 9000
      Completed
      Site FR3003
      Poitiers Cedex, France, 86000
      Completed
      Site RO3039
      Bucharest, RO, Romania, 050659
      Completed
      Site CA3104
      Calgary, AB, Canada, T2V 1P9
      Completed
      Site BE3013
      Turnhout, Belgium, 2300
      Completed
      Site US1675
      Rochester, NY, United States, 14642
      Completed
      Site RO3035
      Bucharest, Romania, 041345
      Withdrawn
      Site US1684
      New York City, NY, United States, 10016
      Completed
      Site US20
      Minneapolis, MN, United States, 55455
      Completed
      Site US1709
      Wenatchee, WA, United States, 98801
      Withdrawn
      Site US3634
      Greenbelt, MD, United States, 20770
      Completed
      Site US3078
      Billings, MT, United States, 59101
      Withdrawn
      Site US3077
      Gainesville, FL, United States, 32608
      Completed
      Site FR3000
      Rennes Cedex, France, 35033
      Withdrawn
      Site US3629
      Tucson, AZ, United States, 85741
      Completed
      Site US464
      Houston, TX, United States, 77030
      Completed
      Site US1527
      Anchorage, AK, United States, 99503
      Completed
      Site US3026
      Tucson, AZ, United States, 85715
      Completed
      Site US81
      Chapel Hill, NC, United States, 27599
      Completed
      Site US51
      Milwaukee, WI, United States, 53226
      Completed
      Site GB3027
      London, UK, United Kingdom, SE19RT
      Withdrawn
      Site CA2973
      Montreal, QC, Canada, H2Z 1N2
      Completed
      Site CA2646
      Kingston, ON, Canada, K7L 2V7
      Completed
      Site GB3290
      Preston, United Kingdom, PR2 9HT
      Completed
      Site US2104
      Greensboro, NC, United States, 27403
      Completed
      Site US2934
      Staten Island, NY, United States, 10304
      Completed
      Site US1657
      Nashville, TN, United States, 37209
      Completed
      Site US1934
      Homewood, AL, United States, 35209
      Completed
      Site US2926
      Myrtle Beach, SC, United States, 29572
      Withdrawn
      Site US2969
      Greenbelt, MD, United States, 20770
      Completed
      Site GB3355
      Merseyside, United Kingdom, CH63 4JY
      Completed
      Site US1653
      Virginia Beach, VA, United States, 23462
      Completed
      Site US2975
      Ann Arbor, MI, United States, 48109
      Completed
      Site FR3009
      Lille, France, 59037
      Completed
      Site US2027
      Jeffersonville, IN, United States, 47130
      Withdrawn
      Site US1649
      Marietta, GA, United States, 30060
      Completed
      Site FR3007
      Rouen, France, 76031
      Completed
      Site GB3244
      Belfast, United Kingdom, BT9 7AB
      Completed
      Site US2968
      Lawrenceville, NJ, United States, 08648
      Completed
      Site FR1091
      Creteil, France, 94010
      Completed
      Site RO3042
      Bucharest, RO, Romania, 022328
      Completed
      Site BE3018
      Kortrijk, Belgium, 8500
      Completed
      Site DK1857
      Copenhagen, Denmark, 2200
      Completed
      Site DE2990
      Hamburg, Hamburg, Germany, 22081
      Withdrawn
      Site US2180
      Fort Wayne, IN, United States, 46825
      Completed
      Site US2935
      Denver, CO, United States, 80211
      Completed
      Site US1680
      Lancaster, PA, United States, 17604
      Completed
      Site US2976
      Baltimore, MD, United States, 21201
      Completed
      Site US2978
      San Antonio, TX, United States, 78229
      Completed
      Site DE3286
      Waldshut-Tiengen, Germany, 29761
      Completed
      Site GB1862
      Leicher, United Kingdom, LE5 4PW
      Completed
      Site FR3002
      Paris Cedex 10, France, 75020
      Completed
      Site DK1263
      Herlev, Denmark, 2730
      Completed
      Site DE2995
      Bonn, Germany, 53111
      Completed
      Site US2067
      Springfield, IL, United States, 62703
      Completed
      Site US3630
      San Diego, CA, United States, 92123
      Completed
      Site DE2992
      Reutlingen, Germany, 72764
      Completed
      Site BE3288
      Leuven, Belgium, 3000
      Completed
      Site GB3163
      London, United Kingdom, NW1 2PG
      Completed
      Site FR3005
      Suresnes Cedex, France, 92151
      Completed
      Site FR442
      Lyon Cedex 3, France, 69437

      Frequently Asked Questions

      Are clinical trials only for people with advanced cancer?

      While some clinical trials may focus on more advanced cancers, many trials are open to patients at various stages of their cancer. Each study has rules about who can take part. For example, only patients in a certain age group or those who have a certain type of tumor may be able to join.

      Will I have to stop my current treatment to participate in a clinical trial?

      Sometimes researchers want participants to keep taking their current treatments during a clinical trial. Other times, you may need to stop your current treatments for a while. If the investigational treatment doesn't work, you can usually go back to your original treatment plan.

      Should I be worried about getting a placebo?

      In cancer clinical trials, a placebo is only used if there is no other treatment for that type of cancer. This helps compare an investigational treatment to the placebo. Placebos are rarely used in cancer trials because the best available treatment, called the “standard of care”, is usually given instead.

      Do I need a referral from my doctor to take part in a study?

      Your doctor may not know about all the opportunities for clinical trials that are available to you. Talk to your doctor or other medical provider about clinical trial information that you find. They can help you decide if a clinical trial is right for you. If you do not find any options on this website, we recommend you visit an online public registry website like clinicaltrials.gov to see a wide variety of available clinical trials.

      Explore More

      1

      What are clinical trials?

      2

      Why are Clinical Trials Important?

      3

      Why Participate in a Clinical Trial?