Study summary

The purpose of this study is to assess the safety and tolerability of ASP9801 and to determine the recommended phase 2 dose (RP2D). The study will also evaluate antitumor activity, objective response rate, pharmacokinetics and virus shedding of ASP9801 as a single agent, as well as in combination with pembrolizumab, an anti-programmed cell death protein 1 (PD-1) checkpoint inhibitor.

Additional Study Details

Phase
Phase 1
Product
Type
Interventional
Masking
None (Open Label)
Enrollment number
72
Show Additional Study Details

Study documents

Scientific Results Summary
Available Language(s): English
Plain Language Summary
Available Language(s): English

Get more information

Would you like more information about clinical trial sites that are recruiting participants for A Study of an Intratumoral Oncolytic Virus in Patients with Advanced Metastatic Solid Tumors? Contact us by filling out your information to the right and we’ll respond to you.

  • A patient
  • A caregiver
  • A parent
  • A healthcare provider
  • A patient advocate
  • Algeria
  • Argentina
  • Armenia
  • Australia
  • Austria
  • Belarus
  • Belgium
  • Bosnia And Herzegovina
  • Brazil
  • Bulgaria
  • Canada
  • Chile
  • China
  • Colombia
  • Croatia
  • Czech Republic
  • Denmark
  • Dominican Republic
  • Egypt
  • Estonia
  • Finland
  • Former Serbia and Montenegro
  • France
  • Georgia
  • Germany
  • Greece
  • Guatemala
  • Hong Kong
  • Hungary
  • Iceland
  • India
  • Indonesia
  • Ireland
  • Israel
  • Italy
  • Japan
  • Jordan
  • Kazakhstan
  • Latvia
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  • Macedonia
  • Malaysia
  • Mexico
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  • Netherlands
  • New Zealand
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  • Panama
  • Peru
  • Philippines
  • Poland
  • Portugal
  • Puerto Rico
  • Republic of Korea
  • Republic of Moldova
  • Romania
  • Russian Federation
  • Saudi Arabia
  • Serbia
  • Singapore
  • Slovakia
  • Slovenia
  • South Africa
  • Spain
  • Sweden
  • Switzerland
  • Taiwan, Province of China
  • Thailand
  • Turkey
  • Ukraine
  • United Kingdom
  • United States
  • Vietnam

By clicking ["Continue/Submit"], you agree that Astellas may contact you by email with information to help you connect with clinical trial sites. While we can connect you to clinical trial sites, we cannot answer questions about any investigational therapy through email. Your consent to receiving emails is not a requirement to participate in a clinical trial or study. For more information, including how to unsubscribe at any time, see our Privacy Notice & Cookies Policy.

    Locations

    Contact Us
    Contact Us
    Withdrawn
    UNC Healthcare
    Chapel Hill, North Carolina, United States, 27514
    Completed
    Mary Crowley Cancer Research Center
    Dallas, TX, United States, 75251
    Withdrawn
    University of Toledo Medical Center
    Toledo, OH, United States, 43614
    Completed
    The Angeles Clinic and Research Institute
    Los Angeles, CA, United States, 90025
    Completed
    Nebraska Methodist Hospital
    Omaha, NE, United States, 68130
    Withdrawn
    Seattle Cancer Care Alliance
    Seattle, WA, United States, 98109
    Completed
    University of Arizona – Arizona Cancer Center
    Tucson, Arizona, United States, 85719
    Withdrawn
    Greenville Health System Cancer Institute
    Greenville, SC, United States, 27605
    Completed
    University of Pittsburgh Medical Center
    Pittsburgh, PA, United States, 15260
    Completed
    The University of Texas - MD Anderson Cancer Center
    Houston, TX, United States, 77030
    Completed
    Henry Ford Hospital
    Detroit, MI, United States, 48202
    Completed
    UVA Cancer Center
    Charlottesville, Virginia, United States, 22903
    Withdrawn
    Ochsner Clinic Foundation
    New Orleans, Louisiana, United States, 70121
    Completed
    Roswell Park Cancer Institute - Medical Oncology
    Buffalo, New York, United States, 14263
    Completed
    University of Maryland Medical Center
    Baltimore, Maryland, United States, 21201
    Withdrawn
    Columbia University Medical Center
    New York, New York, United States, 10032
    Withdrawn
    California Cancer Associates for Research & Excellence
    Encinitas, California, United States, 92024
    Withdrawn
    Hartford Healthcare
    Hartford, Connecticut, United States, 06106
    Completed
    Norton Cancer Institute
    Louisville, Kentucky, United States, 40241
    Completed
    University of Minnesota
    Minneapolis, MN, United States, 55455
    Completed
    VCU Massey Cancer Center
    Richmond, VA, United States, 23298
    Completed
    Fox Chase Cancer Center
    Philadelphia, PA, United States, 19111
    Completed
    University of Alabama at Birmingham
    Birmingham, AL, United States, 35233
    Completed
    The University of Chicago Medical Center
    Chicago, IL, United States, 60637
    Completed
    University of Kentucky, Markey Cancer Center
    Lexington, KY, United States, 40536
    Withdrawn
    Atlantic Health System - Morristown & Overlook Hospital
    Morristown, NJ, United States, 07960
    Withdrawn
    Karmanos Cancer Institute
    Detroit, MI, United States, 48201

    Frequently Asked Questions

    Are clinical trials only for people with advanced cancer?

    While some clinical trials may focus on more advanced cancers, many trials are open to patients at various stages of their cancer. Each study has rules about who can take part. For example, only patients in a certain age group or those who have a certain type of tumor may be able to join.

    Will I have to stop my current treatment to participate in a clinical trial?

    Sometimes researchers want participants to keep taking their current treatments during a clinical trial. Other times, you may need to stop your current treatments for a while. If the investigational treatment doesn't work, you can usually go back to your original treatment plan.

    Should I be worried about getting a placebo?

    In cancer clinical trials, a placebo is only used if there is no other treatment for that type of cancer. This helps compare an investigational treatment to the placebo. Placebos are rarely used in cancer trials because the best available treatment, called the “standard of care”, is usually given instead.

    Do I need a referral from my doctor to take part in a study?

    Your doctor may not know about all the opportunities for clinical trials that are available to you. Talk to your doctor or other medical provider about clinical trial information that you find. They can help you decide if a clinical trial is right for you. If you do not find any options on this website, we recommend you visit an online public registry website like clinicaltrials.gov to see a wide variety of available clinical trials.

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