Study summary

This study is being done to see how well two drugs (enfortumab vedotin and pembrolizumab) work together as a bladder preservation approach to treat patients with muscle invasive bladder cancer. The study will compare these drugs to concurrent chemoradiotherapy that is usually used to treat this cancer (standard of care). The study will enroll patients with muscle-invasive bladder cancer (MIBC) who have cancer that has not spread outside the bladder.

Additional Study Details

Phase
Phase 3
Product
enfortumab vedotin
Product
Enfortumab vedotin
Cisplatin
Fluorouracil
Mitomycin C
Gemcitabine
Pembrolizumab
Type
Interventional
Masking
None (Open Label)
Enrollment number
390
Show Additional Study Details

Get more information

Would you like more information about clinical trial sites that are recruiting participants for Enfortumab Vedotin in Combination With Pembrolizumab vs. Concurrent Chemoradiotherapy (cCRT) in People With Muscle Invasive Bladder Cancer (EV-309)? Contact us by filling out your information to the right and we’ll respond to you.

  • A caregiver
  • A healthcare provider
  • A parent
  • A patient
  • A patient advocate
  • Algeria
  • Argentina
  • Armenia
  • Australia
  • Austria
  • Belarus
  • Belgium
  • Bosnia And Herzegovina
  • Brazil
  • Bulgaria
  • Canada
  • Chile
  • China
  • Colombia
  • Croatia
  • Czech Republic
  • Denmark
  • Dominican Republic
  • Egypt
  • Estonia
  • Finland
  • Former Serbia and Montenegro
  • France
  • Georgia
  • Germany
  • Greece
  • Guatemala
  • Hong Kong
  • Hungary
  • Iceland
  • India
  • Indonesia
  • Ireland
  • Israel
  • Italy
  • Japan
  • Jordan
  • Kazakhstan
  • Latvia
  • Lebanon
  • Lithuania
  • Macedonia
  • Malaysia
  • Mexico
  • Montenegro
  • Morocco
  • Netherlands
  • New Zealand
  • Norway
  • Panama
  • Peru
  • Philippines
  • Poland
  • Portugal
  • Puerto Rico
  • Republic of Korea
  • Republic of Moldova
  • Romania
  • Russian Federation
  • Saudi Arabia
  • Serbia
  • Singapore
  • Slovakia
  • Slovenia
  • South Africa
  • Spain
  • Sweden
  • Switzerland
  • Taiwan, Province of China
  • Thailand
  • Turkey
  • Ukraine
  • United Kingdom
  • United States
  • Vietnam

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    Locations

    Contact Us
    Contact Us
    Recruiting
    Texas Oncology
    Austin, Texas, United States, 78705
    Recruiting
    SCRI Oncology Partners
    Nashville, TN, United States, 37203
    Recruiting
    Medical Oncology Hematology Consultants
    Newark, DE, United States, 19713
    Recruiting
    Samsun Clinic - Ridley-Tree Cancer Center
    Santa Barbara, CA, United States, 93105
    Recruiting
    Illinois Cancer Specialists
    Niles, IL, United States, 60714
    Recruiting
    Compass Oncology – West
    Tigard, OR, United States, 97223
    Recruiting
    Virginia Oncology Associates
    Norfolk, VA, United States, 23502
    Recruiting
    Texas Oncology - Northeast Texas
    Tyler, TX, United States, 75702
    Recruiting
    Williamette Valley Cancer Institute and Research Center
    Eugene, OR, United States, 97401
    Recruiting
    Fort Wayne Medical Oncology and Hematology
    Fort Wayne, IN, United States, 46825
    Recruiting
    Missouri Cancer Associates
    Columbia, MO, United States, 65201
    Recruiting
    Rocky Mountain Cancer Center
    Aurora, CO, United States, 80012

    Frequently Asked Questions

    Are clinical trials only for people with advanced cancer?

    While some clinical trials may focus on more advanced cancers, many trials are open to patients at various stages of their cancer. Each study has rules about who can take part. For example, only patients in a certain age group or those who have a certain type of tumor may be able to join.

    Will I have to stop my current treatment to participate in a clinical trial?

    Sometimes researchers want participants to keep taking their current treatments during a clinical trial. Other times, you may need to stop your current treatments for a while. If the investigational treatment doesn't work, you can usually go back to your original treatment plan.

    Should I be worried about getting a placebo?

    In cancer clinical trials, a placebo is only used if there is no other treatment for that type of cancer. This helps compare an investigational treatment to the placebo. Placebos are rarely used in cancer trials because the best available treatment, called the “standard of care”, is usually given instead.

    Do I need a referral from my doctor to take part in a study?

    Your doctor may not know about all the opportunities for clinical trials that are available to you. Talk to your doctor or other medical provider about clinical trial information that you find. They can help you decide if a clinical trial is right for you. If you do not find any options on this website, we recommend you visit an online public registry website like clinicaltrials.gov to see a wide variety of available clinical trials.

    Explore More

    1

    What are clinical trials?

    2

    Why are Clinical Trials Important?

    3

    Why Participate in a Clinical Trial?