Study summary

The purpose of this trial is to evaluate a CMV vaccine given to related donor/recipient pairs (donors prior to peripheral blood stem cell donation and CMV-seropositive recipients just before and after transplantation) and CMV-seropositive recipient-only subjects (related or unrelated) to determine incidence rates of CMV infection, disease, and other complications from immunosuppression and/or transplantation. The outcomes for the groups receiving CMV vaccine will be compared to the outcomes for the group that received the placebo vaccine to see if there is a clinical benefit. For this trial, donors and recipients must have matched HLA genotype (matched at 5/6 or 6/6 HLA loci).

Additional Study Details

Phase
Phase 2
Product
N/A
Type
Interventional
Masking
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Enrollment number
108
Show Additional Study Details

Study documents

Clinical Study Report
Available Language(s): English
Plain Language Summary
Available Language(s): English

Get more information

Would you like more information about clinical trial sites that are recruiting participants for Cytomegalovirus (CMV) vaccine in donors and recipients undergoing allogeneic hematopoietic cell transplant (HCT)? Contact us by filling out your information to the right and we’ll respond to you.

  • A caregiver
  • A healthcare provider
  • A parent
  • A patient
  • A patient advocate
  • Algeria
  • Argentina
  • Armenia
  • Australia
  • Austria
  • Belarus
  • Belgium
  • Bosnia And Herzegovina
  • Brazil
  • Bulgaria
  • Canada
  • Chile
  • China
  • Colombia
  • Croatia
  • Czech Republic
  • Denmark
  • Dominican Republic
  • Egypt
  • Estonia
  • Finland
  • Former Serbia and Montenegro
  • France
  • Georgia
  • Germany
  • Greece
  • Guatemala
  • Hong Kong
  • Hungary
  • Iceland
  • India
  • Indonesia
  • Ireland
  • Israel
  • Italy
  • Japan
  • Jordan
  • Kazakhstan
  • Latvia
  • Lebanon
  • Lithuania
  • Macedonia
  • Malaysia
  • Mexico
  • Montenegro
  • Morocco
  • Netherlands
  • New Zealand
  • Norway
  • Panama
  • Peru
  • Philippines
  • Poland
  • Portugal
  • Puerto Rico
  • Republic of Korea
  • Republic of Moldova
  • Romania
  • Russian Federation
  • Saudi Arabia
  • Serbia
  • Singapore
  • Slovakia
  • Slovenia
  • South Africa
  • Spain
  • Sweden
  • Switzerland
  • Taiwan, Province of China
  • Thailand
  • Turkey
  • Ukraine
  • United Kingdom
  • United States
  • Vietnam

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    Locations

    Contact Us
    Contact Us
    Terminated
    Mayo Clinic
    Rochester, Minnesota, United States, 55905
    Completed
    Memorial Sloan Kettering Cancer Center
    New York, New York, United States, 10021
    Completed
    Montefiore Medical Center
    Bronx, New York, United States, 10467
    Terminated
    University of Chicago
    Chicago, Illinois, United States, 60637
    Completed
    Baylor University Medical Center
    Dallas, Texas, United States, 75246
    Completed
    City of Hope National Medical Center
    Duarte, CA, United States, 91010
    Completed
    Arizona Cancer Center
    Tucson, Arizona, United States, 85724
    Completed
    Karmanos Cancer Institute
    Detroit, Michigan, United States, 48201
    Completed
    Strong Memorial Hospital
    Rochester, New York, United States, 14642
    Completed
    Fred Hutchinson Cancer Research Center
    Seattle, Washington, United States, 98109-1024
    Completed
    University of South Florida
    Tampa, Florida, United States, 33612
    Completed
    Hackensack University Medical Center # 408
    Hackensack, NJ, United States, 07601
    Terminated
    Rocky Mountain Cancer Center
    Denver, Colorado, United States, 80218
    Completed
    University of Nebraska Medical Center
    Omaha, Nebraska, United States, 68198
    Completed
    Emory University
    Atlanta, GA, United States, 30322
    Terminated
    North Carolina Baptist Hosptial
    Winston-Salem, NC, United States, 27157
    Terminated
    James Graham Brown Cancer Center
    Louisville, KY, United States, 40202
    Completed
    University of Kansas Medical Center
    Westwood, Kansas, United States, 66205
    Completed
    Brigham and Women's Hospital
    Boston, Massachusetts, United States, 02115
    Terminated
    Rush University Medical Center
    Chicago, IL, United States, 60612
    Terminated
    University of Texas Southwestern Medical Center at Dallas
    Dallas, Texas, United States, 75390
    Completed
    Roswell Park Cancer Institute Corporation
    Buffalo, New York, United States, 14263

    Frequently Asked Questions

    Are clinical trials only for people with advanced cancer?

    While some clinical trials may focus on more advanced cancers, many trials are open to patients at various stages of their cancer. Each study has rules about who can take part. For example, only patients in a certain age group or those who have a certain type of tumor may be able to join.

    Will I have to stop my current treatment to participate in a clinical trial?

    Sometimes researchers want participants to keep taking their current treatments during a clinical trial. Other times, you may need to stop your current treatments for a while. If the investigational treatment doesn't work, you can usually go back to your original treatment plan.

    Should I be worried about getting a placebo?

    In cancer clinical trials, a placebo is only used if there is no other treatment for that type of cancer. This helps compare an investigational treatment to the placebo. Placebos are rarely used in cancer trials because the best available treatment, called the “standard of care”, is usually given instead.

    Do I need a referral from my doctor to take part in a study?

    Your doctor may not know about all the opportunities for clinical trials that are available to you. Talk to your doctor or other medical provider about clinical trial information that you find. They can help you decide if a clinical trial is right for you. If you do not find any options on this website, we recommend you visit an online public registry website like clinicaltrials.gov to see a wide variety of available clinical trials.

    Explore More

    1

    What are clinical trials?

    2

    Why are Clinical Trials Important?

    3

    Why Participate in a Clinical Trial?