Study summary

IMAB362 is a monoclonal antibody specific for gastric or lower esophageal adenocarcinoma. Preclinically IMAB362 was shown to inhibit tumor growth and to kill cancer cells by indirect (complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity) and direct mechanisms (antiproliferative and proapoptotic effects). The aim of this phase II study is to establish efficacy and safety of multiple doses of IMAB362 as monotherapy in patients suffering from metastatic, refractory or recurrent adenocarcinoma of the stomach or the lower esophagus.

Additional Study Details

Phase
Phase 2
Product
  • IMAB362
  • Type
    Interventional
    Masking
    None (Open Label)
    Enrollment number
    54
    Show Additional Study Details

    Study documents

    Scientific Results Summary
    Available Language(s): English
    Plain Language Summary
    Available Language(s): English

    Get more information

    Would you like more information about clinical trial sites that are recruiting participants for Efficacy and Safety Study of Multiple Doses of IMAB362 in Patients With Advanced Gastroesophageal Cancer? Contact us by filling out your information to the right and we’ll respond to you.

    • A caregiver
    • A healthcare provider
    • A parent
    • A patient
    • A patient advocate
    • Algeria
    • Argentina
    • Armenia
    • Australia
    • Austria
    • Belarus
    • Belgium
    • Bosnia And Herzegovina
    • Brazil
    • Bulgaria
    • Canada
    • Chile
    • China
    • Colombia
    • Croatia
    • Czech Republic
    • Denmark
    • Dominican Republic
    • Egypt
    • Estonia
    • Finland
    • Former Serbia and Montenegro
    • France
    • Georgia
    • Germany
    • Greece
    • Guatemala
    • Hong Kong
    • Hungary
    • Iceland
    • India
    • Indonesia
    • Ireland
    • Israel
    • Italy
    • Japan
    • Jordan
    • Kazakhstan
    • Latvia
    • Lebanon
    • Lithuania
    • Macedonia
    • Malaysia
    • Mexico
    • Montenegro
    • Morocco
    • Netherlands
    • New Zealand
    • Norway
    • Panama
    • Peru
    • Philippines
    • Poland
    • Portugal
    • Puerto Rico
    • Republic of Korea
    • Republic of Moldova
    • Romania
    • Russian Federation
    • Saudi Arabia
    • Serbia
    • Singapore
    • Slovakia
    • Slovenia
    • South Africa
    • Spain
    • Sweden
    • Switzerland
    • Taiwan, Province of China
    • Thailand
    • Turkey
    • Ukraine
    • United Kingdom
    • United States
    • Vietnam

    By clicking ["Continue/Submit"], you agree that Astellas may contact you by email with information to help you connect with clinical trial sites. While we can connect you to clinical trial sites, we cannot answer questions about any investigational therapy through email. Your consent to receiving emails is not a requirement to participate in a clinical trial or study. For more information, including how to unsubscribe at any time, see our Privacy Notice & Cookies Policy.

      Locations

      Contact Us
      Contact Us
      Completed
      Universitätsklinikum Essen, Innere Klinik (Tumorforschung)
      Essen, Germany, 45122
      Completed
      Piejuras Hospital
      Liepaja, Latvia
      Active, not recruiting
      Paula Stradina Clinical University Hospital
      Riga, Latvia, 1002
      Completed
      Krankenhaus Nordwest, Klinik für Onkologie und Hämatologie
      Frankfurt, Germany, 60488
      Active, not recruiting
      Universitätsklinikum Heidelberg, NCT
      Heidelberg, Germany, 69120
      Withdrawn
      Medizinische Universität Wien
      Wien, Austria, 1090
      Completed
      Universitätsmedizin der Johannes-Gutenberg Universität
      Mainz, Germany, 55101
      Completed
      Vilnius University
      Vilnius, Lithuania, 08660
      Completed
      Kantonsspital St. Gallen
      St.Gallen, Switzerland, 9007
      Completed
      Klinikum Braunschweig
      Braunschweig, Germany, 38114
      Completed
      Universitätsklinikum Halle
      Halle, Germany, 06120
      Completed
      Universitätsklinikum Leipzig
      Leipzig, Germany, 04103
      Completed
      Medizinische Univeritätsklinik Ruhr-Universität Bochum
      Bochum, Germany, 44892
      Active, not recruiting
      Riga East Clinical Research
      Riga, Latvia, 1038
      Completed
      Klinikum rechts der Isar
      Muenchen, Germany, 81675
      Completed
      Charité - Universitätsmedizin Berlin
      Berlin, Germany, 13353
      Completed
      Oncology Dispensary "Dr. Marko Markov"
      Varna, Bulgaria, 9002
      Completed
      MHAT "St.Marina"
      Varna, Bulgaria, 9010
      Completed
      Complex Oncology Center
      Veliko Turnovo, Bulgaria, 5000
      Completed
      Universitäres Cancer Center Universitätsklinikum Eppendorf
      Hamburg, Germany, 20246
      Completed
      Onkologische Schwerpunktpraxis Eppendorf
      Hamburg, Germany, 20249
      Completed
      Universitätsklinikum Ulm
      Ulm, Germany, 89081

      Frequently Asked Questions

      Are clinical trials only for people with advanced cancer?

      While some clinical trials may focus on more advanced cancers, many trials are open to patients at various stages of their cancer. Each study has rules about who can take part. For example, only patients in a certain age group or those who have a certain type of tumor may be able to join.

      Will I have to stop my current treatment to participate in a clinical trial?

      Sometimes researchers want participants to keep taking their current treatments during a clinical trial. Other times, you may need to stop your current treatments for a while. If the investigational treatment doesn't work, you can usually go back to your original treatment plan.

      Should I be worried about getting a placebo?

      In cancer clinical trials, a placebo is only used if there is no other treatment for that type of cancer. This helps compare an investigational treatment to the placebo. Placebos are rarely used in cancer trials because the best available treatment, called the “standard of care”, is usually given instead.

      Do I need a referral from my doctor to take part in a study?

      Your doctor may not know about all the opportunities for clinical trials that are available to you. Talk to your doctor or other medical provider about clinical trial information that you find. They can help you decide if a clinical trial is right for you. If you do not find any options on this website, we recommend you visit an online public registry website like clinicaltrials.gov to see a wide variety of available clinical trials.

      Explore More

      1

      What are clinical trials?

      2

      Why are Clinical Trials Important?

      3

      Why Participate in a Clinical Trial?