Study summary

The objectives of this study was to evaluate the safety and efficacy of avacincaptad pegol intravitreal administration in participants with geographic atrophy secondary to age-related macular degeneration (AMD)

Additional Study Details

Phase
Phase 3
Product
  • Avacincaptad Pegol
  • Sham
  • Type
    Interventional
    Masking
    Double (Participant, Outcomes Assessor)
    Enrollment number
    448
    Show Additional Study Details

    Study documents

    Scientific Results Summary
    Available Language(s): English
    Plain Language Summary
    Available Language(s): English
    Protocol
    Available Language(s): English
    Statistical Analysis Plan (SAP)
    Available Language(s): English

    Get more information

    Would you like more information about clinical trial sites that are recruiting participants for A Phase 3 Safety and Efficacy Study of Intravitreal Administration of Zimura (Complement C5 Inhibitor)? Contact us by filling out your information to the right and we’ll respond to you.

    • A patient
    • A caregiver
    • A parent
    • A healthcare provider
    • A patient advocate
    • Algeria
    • Argentina
    • Armenia
    • Australia
    • Austria
    • Belarus
    • Belgium
    • Bosnia And Herzegovina
    • Brazil
    • Bulgaria
    • Canada
    • Chile
    • China
    • Colombia
    • Croatia
    • Czech Republic
    • Denmark
    • Dominican Republic
    • Egypt
    • Estonia
    • Finland
    • Former Serbia and Montenegro
    • France
    • Georgia
    • Germany
    • Greece
    • Guatemala
    • Hong Kong
    • Hungary
    • Iceland
    • India
    • Indonesia
    • Ireland
    • Israel
    • Italy
    • Japan
    • Jordan
    • Kazakhstan
    • Latvia
    • Lebanon
    • Lithuania
    • Macedonia
    • Malaysia
    • Mexico
    • Montenegro
    • Morocco
    • Netherlands
    • New Zealand
    • Norway
    • Panama
    • Peru
    • Philippines
    • Poland
    • Portugal
    • Puerto Rico
    • Republic of Korea
    • Republic of Moldova
    • Romania
    • Russian Federation
    • Saudi Arabia
    • Serbia
    • Singapore
    • Slovakia
    • Slovenia
    • South Africa
    • Spain
    • Sweden
    • Switzerland
    • Taiwan, Province of China
    • Thailand
    • Turkey
    • Ukraine
    • United Kingdom
    • United States
    • Vietnam

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      Locations

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      Completed
      Retina-Vitreous Associates Medical Group
      Beverly Hills, California, United States, 90211
      Completed
      Retinal Diagnostic Center
      Campbell, California, United States, 95008
      Completed
      Eye Medical Center of Fresno
      Fresno, California, United States, 93720
      Completed
      Retina Consultants of Orange County
      Fullerton, California, United States, 92835
      Completed
      University of California, San Diego
      La Jolla, California, United States, 92093
      Completed
      Jules Stein Eye Institute/David Geffen School of Medicine
      Los Angeles, California, United States, 90095
      Completed
      Northern California Retina Vitreous Associates
      Mountain View, California, United States, 94040
      Completed
      California Retina Consultants
      Oxnard, California, United States, 93036
      Completed
      Southern California Desert Retina Consultants
      Palm Desert, California, United States, 92211
      Completed
      Doheny Eye Center, UCLA
      Pasadena, California, United States, 91105
      Completed
      Retina Consultants of Southern California
      Redlands, California, United States, 92374
      Completed
      Retinal Consultants Medical Group, Inc.
      Sacramento, California, United States, 95825
      Completed
      Orange County Retinal Medical Group
      Santa Ana, California, United States, 92705
      Completed
      University of Colorado
      Aurora, Colorado, United States, 80045
      Completed
      Retina Consultants of Southern Colorado, P.C.
      Colorado Springs, Colorado, United States, 80909
      Completed
      Colorado Retina Associates
      Lakewood, Colorado, United States, 80228
      Completed
      Connecticut Eye Consultants, P.C.
      Danbury, Connecticut, United States, 06810
      Completed
      Retina Group of New England, PC
      Waterford, Connecticut, United States, 06385
      Completed
      Florida Eye Clinic
      Altamonte Springs, Florida, United States, 32701
      Completed
      Rand Eye Institute
      Deerfield Beach, Florida, United States, 33064
      Completed
      Retina Group of Florida
      Fort Lauderdale, Florida, United States, 33308
      Completed
      National Ophthalmic Research Institute
      Fort Myers, Florida, United States, 33912
      Completed
      Retina Health Center
      Fort Myers, Florida, United States, 33907
      Completed
      VitreoRetinal Associates, P.A.
      Gainesville, Florida, United States, 32607
      Completed
      Florida Eye Associates
      Melbourne, Florida, United States, 32901
      Completed
      University of Miami-Bascom Palmer Eye Institute
      Miami, Florida, United States, 33136
      Completed
      Retina Care Specialists
      Palm Beach Gardens, Florida, United States, 33410
      Completed
      Retina Specialty Institute
      Pensacola, Florida, United States, 32503
      Completed
      Retina Vitreous Associates of Florida
      Saint Petersburg, Florida, United States, 33711
      Completed
      Retina Associates of Sarasota
      Sarasota, Florida, United States, 34233
      Completed
      East Florida Eye Institute
      Stuart, Florida, United States, 34994
      Completed
      Southern Vitreoretinal Associates, PL
      Tallahassee, Florida, United States, 32308
      Completed
      Center for Retina and Macula Disease
      Winter Haven, Florida, United States, 33880
      Completed
      Southeast Retina Center
      Augusta, Georgia, United States, 30909
      Completed
      Georgia Retina, P.C.
      Marietta, Georgia, United States, 30060
      Completed
      Retina Consultants of Hawaii, Inc
      'Aiea, Hawaii, United States, 96701
      Completed
      University Retina and Macula Associates, PC
      Lemont, Illinois, United States, 60439
      Completed
      Illinois Eye Center
      Peoria, Illinois, United States, 61615
      Completed
      Midwest Eye Institute
      Indianapolis, Indiana, United States, 46290
      Completed
      Wolfe Eye Clinic
      West Des Moines, Iowa, United States, 50266
      Completed
      Retina Associates, LLC
      Lenexa, Kansas, United States, 66215
      Completed
      Vitreo Retinal Consultants & Surgeons
      Wichita, Kansas, United States, 67214
      Completed
      Ochsner Medical Center
      New Orleans, Louisiana, United States, 70121
      Completed
      The Retina Care Center
      Baltimore, Maryland, United States, 21209
      Completed
      The Retina Group of Washington
      Chevy Chase, Maryland, United States, 20815
      Completed
      Cumberland Valley Retina Consultants
      Hagerstown, Maryland, United States, 21740
      Completed
      Ophthalmic Consultants of Boston
      Boston, Massachusetts, United States, 02114
      Completed
      Retina Research Institute at New England Retinal Consultants
      Springfield, Massachusetts, United States, 01107
      Completed
      Vitreoretinal Associates, PC
      Worcester, Massachusetts, United States, 01605
      Completed
      UMASS Memorial Eye Center
      Worcester, Massachusetts, United States, 01605
      Completed
      Associated Retinal Consultants, P.C.
      Royal Oak, Michigan, United States, 48073
      Completed
       Retina Center
      Minneapolis, Minnesota, United States, 55404
      Completed
      St. Louis University
      Saint Louis, Missouri, United States, 63110
      Completed
      Retina Consultants of Nevada
      Henderson, Nevada, United States, 89052
      Completed
      Sierra Eye Associates
      Reno, Nevada, United States, 89502
      Completed
      Retina Center of New Jersey, LLC
      Bloomfield, New Jersey, United States, 07003
      Completed
      Long Island Vitreoretinal Consultant
      Great Neck, New York, United States, 11021
      Completed
      Retina Vitreous Surgeons of Central New York, PC
      Liverpool, New York, United States, 13088
      Completed
      Vitreous Retina Macula Consultants of New York (VRMNY)
      New York, New York, United States, 10022
      Completed
      OCLI
      Oceanside, New York, United States, 11572
      Completed
      Retina Associates of Western NY, PC
      Rochester, New York, United States, 14620
      Completed
      Ophthalmic Consultants of the Capital Region
      Troy, New York, United States, 12180
      Completed
      Western Carolina Retinal Associates
      Asheville, North Carolina, United States, 28803
      Completed
      Cincinnati Eye Institute
      Cincinnati, Ohio, United States, 45242
      Completed
      Retina and Vitreous Center of Southern Oregon
      Ashland, OREGON, United States, 97520
      Completed
      Casey Eye Institute
      Portland, OREGON, United States, 97239
      Completed
      EyeHealth Northwest
      Portland, OREGON, United States, 97225
      Completed
      Retina Northwest, PC
      Portland, OREGON, United States, 97221
      Completed
      Mid Atlantic Retina
      Philadelphia, Pennsylvania, United States, 19107
      Completed
      Scheie Eye Institute, University of Pennsylvania
      Philadelphia, Pennsylvania, United States, 19104
      Completed
      Associates in Ophthalmology, Ltd
      West Mifflin, Pennsylvania, United States, 15122
      Completed
      Retina Research of Beaufort, LLC
      Beaufort, South Carolina, United States, 29902
      Completed
      Charleston Neuroscience Institute
      Ladson, South Carolina, United States, 29456
      Completed
      Carolina Macula and Retina
      Mount Pleasant, South Carolina, United States, 29464
      Completed
      Palmetto Retina Center
      West Columbia, South Carolina, United States, 29169
      Completed
      Black Hills Regional Eye Institute
      Rapid City, South Dakota, United States, 57701
      Completed
      Southeastern Retina Associates, PC
      Johnson City, Tennessee, United States, 37604
      Completed
      Southeastern Retina Associates, PC
      Knoxville, Tennessee, United States, 37922
      Completed
      Retina Research Institute of Texas
      Abilene, Texas, United States, 79606
      Completed
      Southwest Retina Specialists
      Amarillo, Texas, United States, 79106
      Completed
      Austin Retina Associates
      Austin, Texas, United States, 78705
      Completed
      Retina Foundation of the Southwest
      Dallas, Texas, United States, 75231
      Completed
      Retina and Vitreous of Texas, PLLC
      Houston, Texas, United States, 77025
      Completed
      Valley Retina Institute
      McAllen, Texas, United States, 78503
      Completed
      Medical Center Ophthalmology Associates
      San Antonio, Texas, United States, 78240
      Completed
      Retina Center of Texas
      Southlake, Texas, United States, 76092
      Completed
      Retinal Consultants of Houston
      The Woodlands, Texas, United States, 77384
      Completed
      Strategic Clinical Research Group
      Willow Park, Texas, United States, 76087
      Completed
      Rocky Mountain Retina Consultants
      Salt Lake City, Utah, United States, 84107
      Completed
      University of Utah, John A. Moran Eye Center
      Salt Lake City, Utah, United States, 84132
      Completed
      Retinal Associates of Utah
      Salt Lake City, Utah, United States, 84107
      Completed
      Wagner Macular & Retina Center
      Norfolk, Virginia, United States, 23502
      Completed
      Retina Institute of Virginia
      Richmond, Virginia, United States, 23235
      Completed
      Vistar Eye Center
      Roanoke, Virginia, United States, 24018
      Completed
      Pacific Northwest Retina
      Bellevue, Washington, United States, 98004
      Completed
      Retina Center NW, PLLC
      Silverdale, Washington, United States, 98383
      Completed
      Instituto Oftalmológico de Buenos Aires
      Buenos Aires, Argentina, C1120AAN
      Completed
      Instituto Oftalmológico de Córdoba
      Córdoba, Argentina, X5000III
      Completed
      Centro Privado de Ojos Romagosa S.A.
      Córdoba, Córdoba, Argentina, X5000AAJ
      Completed
      Centro Privado de Oftalmologia - OFTAR Mendoza SRL
      Mendoza, Argentina, M5500GGK
      Completed
      Centro Medico Micro Diagnostico y Microcirugla Ocular
      Rosario, Argentina, S2000TC
      Completed
      Buenos Aires Macula S.A.
      Buenos Aires, CABA, Argentina, Cl061AAE
      Completed
      Centro Oftalmológico Dr. Charles SA
      Buenos Aires, CABA, Argentina, C1116ABA
      Completed
      Centro de Diagnóstico y Cirugía Ocular "Oftalmólogos Especialistas"
      Rosario, Santa Fe, Argentina, S2000ANJ
      Completed
      Centro Médico Grupo Laser Visión
      Rosario, Santa Fe, Argentina, CP2000
      Completed
      Royal Victorian Eye & Ear Hospital
      East Melbourne, Australia, 3002
      Completed
      Sydney Eye Hospital
      Sydney, NSW, Australia, 2000
      Completed
      Sydney Retina Clinic and Day Surgery
      Sydney, NSW, Australia, 2000
      Completed
      Medizinische Universitaet Graz - Augenklinik
      Graz, Austria, 8036
      Completed
      Medizinische Universitaet Innsbruck - Universitaetsklinik fuer Augenheilkunde und Optometrie
      Innsbruck, Austria, 6020
      Completed
      Hanush Hospital
      Vienna, Austria, 1140
      Completed
      Medical University of Vienna
      Vienna, Austria, 1090
      Completed
      CHU Brugmann
      Brussels, Belgium
      Completed
      Centro de Ensino e Pesquisa do Instituto da Visao (CEPIV)
      Belo Horizonte, Brazil, 30330
      Completed
      IPEPO - Instituto da visão
      São Paulo, Brazil, 04038-032
      Completed
      Hospital Sao Paulo - UNIFESP
      Vila Clementino, Brazil, 04023-062
      Completed
      Retina Centre of Ottawa
      Ottawa, Canada, K2B 7E9
      Completed
      Calgary Retina Consultants
      Calgary, Alberta, Canada, T2H 0C8
      Completed
      UBC/VGH Eye Care Center
      Vancouver, British Columbia, Canada, V5Z3N9
      Completed
      Canadian Centre for Advanced Eye Therapeutics Inc.
      Mississauga, ON, Canada, L4W 1W9
      Completed
      St.Joseph's Health Care London
      London, Ontario, Canada, N6A4V2
      Completed
      University of Ottawa Eye Institute
      Ottawa, Ontario, Canada, K1H8L6
      Completed
      University Health Network
      Toronto, Ontario, Canada, M5T 2S8
      Completed
      Fundacion OJlalmologica Nacional - FUNDONAL
      Bogotá, Colombia, 110311
      Completed
      Clinica De Oftalmologia Sandiego
      Medellín, Antioquia, Colombia, 050016
      Completed
      Clinical hospital Center Osijek
      Osijek, Croatia, 31000
      Completed
      Axon Clinical s.r.o.
      Prague, Smichov, Czech Republic, 150 00
      Completed
      Dr Kai Noor Silmakabinet
      Tallin, Estonia, 11412
      Completed
      Tartu University Hospital
      Tartu, Estonia, 50406
      Completed
      CHU de Bordeaux – Hopital Pellegrin
      Bordeaux, France, 33000
      Completed
      Hopital Intercommunal
      Créteil, France, 94010
      Completed
      CHU Bocage
      Dijon, France, 21079
      Completed
      Hopital de la Croix Rousse
      Lyon, France, 69004
      Completed
      Centre d'ophtalmologie Rabelais
      Lyon, France, 69002
      Completed
      Centre Paradis Monticelli
      Marseille, France, 13008
      Completed
      CHU de Nantes
      Nantes, France, 44043
      Completed
      Centre Ophtalmologique d'Imagerie et de Laser
      Paris, France, 75015
      Completed
      Centre d'exploration ophtalmologique de l'Odeon
      Paris, France, 75006
      Completed
      Hôpital Lariboisière
      Paris, France, 75010
      Completed
      Fondation Alolphe de Rotschild
      Paris, France, 75019
      Completed
      Centre St Exupery
      Saint-Cyr-sur-Loire, France, 37540
      Completed
      Centre Pole Vision Val d'Ouest
      Écully, France, 69130
      Completed
      RWTH Aachen University
      Aachen, Germany, 52074
      Completed
      University of Göttingen
      Göttingen, Germany, 37075
      Completed
      Universitätsklinikum Hamburg Eppendorf Klinik und Poliklinik für Augenheilkunde Studienzentrum
      Hamburg, Germany, 20251
      Completed
      University Eye Hospital, MHH
      Hanover, Germany, 30625
      Completed
      Augenklinik University Hospital Cologne
      Köln, Germany, 50937
      Completed
      University clinic Leipzig AÖR
      Leipzig, Germany, 04103
      Completed
      Universitätsklinikum Schleswig-Holstein
      Lübeck, Germany, 23538
      Completed
      Universitätsmedizin der Johannes Gutenberg-Universität Mainz
      Mainz, Germany, 55131
      Completed
      Clinic Rechts der Isar
      Munich, Germany, 81675
      Completed
      Ludwig-Maximilians-University Munich
      Munich, Germany, 80336
      Completed
      Universitätsklinikum Münster
      Münster, Germany, 48149
      Completed
      Augenzentrum am St. Franziskus-Hospital
      Münster, Germany, 48145
      Completed
      Universitäts-Augenklinik
      Tübingen, Germany, 72076
      Completed
      Budapest Retina Associates
      Budapest, Hungary, 1133
      Completed
      Bajcsy Zsilinszky Kórház - Szemészet
      Budapest, Hungary, 1106
      Completed
      Semmelweis University, Dept of Ophthalmology
      Budapest, Hungary, H-1085
      Completed
      Hungarian Military Hospital Center
      Budapest, Hungary, 1068
      Completed
      Debrecen University Clinical Center, Dept of Ophthalmology
      Debrecen, Hungary, H-4032
      Completed
      Szabolcs-Szatmar-Bereg County Hospital and University Teaching Hospital
      Nyiregyhaza, Hungary, 4400
      Completed
      Ganglion Medical Center
      Pécs, Hungary, H-7621
      Completed
      Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont
      Szeged, Hungary, H-6720
      Completed
      Barzilai Medical Center
      Ashkelon, Israel, 7830604
      Completed
      Shamir Medical Center
      Be'er Ya'aqov, Israel, 70300
      Completed
      Rambam Medical Centre
      Haifa, Israel, 3109601
      Completed
      Carmel Medical Center
      Haifa, Israel, 3436212
      Completed
      Edith Wolfson Medical Center
      Holon, Israel, 5822012
      Completed
      Hadassah University Hospital
      Jerusalem, Israel, 91120
      Completed
      Department of Ophthalmology, Rabin Medical Center
      Petah tikva, Israel, 49100
      Completed
      Kaplan Medical Center
      Reẖovot, Israel, 76100
      Completed
      Sourasky Medical Center
      Tel Aviv, Israel, 6423906
      Completed
      Ospedali Riuniti di Ancona
      Ancona, Italy, 60126
      Completed
      A.O.U. Policlinico Sant'Orsola-Malpighi
      Bologna, Italy, 40138
      Completed
      Ospedale Clinicizzato Universita di Chieti "Ss Annunziata"
      Chieti, Italy, 66100
      Completed
      Nuovo Arcispedale Sant' Anna (A.O.U. di Ferrara)
      Ferrara, Italy, 44124
      Completed
      Azienda Ospedaliera Universitaria Careggi
      Florence, Italy, 50134
      Completed
      IRCCS Ospedale San Raffaele
      Milan, Italy, 20132
      Completed
      Ospedale Luigi Sacco
      Milan, Italy, 20157
      Completed
      Ospedale Maggiore Policlinico Milano
      Milan, Italy, 20122
      Completed
      AOU Universita degli Studi della Campania Luigi Vanvitelli UOC Oculistica
      Naples, Italy, 80131
      Completed
      Azienda Ospedaliera di Padova Unità Operativa Complessa di Clinica Oculistica
      Padova, Italy, 35128
      Completed
      University of Pisa
      Pisa, Italy, 56126
      Completed
      Fondazione GB Bietti IRCCS
      Roma, Italy, 00198
      Completed
      Fondazione PTV
      Roma, Italy, 00133
      Completed
      Azienda Sanitaria Universitaria Integrata
      Udine, Italy, 33100
      Completed
      Pauls Stradinis Clinical University Hospital
      Riga, Latvia, LV-1002
      Completed
      Klinika Okulistyczna OFT ALMIKA Sp. z o. o.
      Bydgoszcz, Poland, 85-631
      Completed
      Caminomed
      Tarnowskie Góry, Poland, 42-600
      Completed
      Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego
      Wrocław, Poland, 50-556
      Completed
      Medical Center Julianów
      Łódź, Poland, 91-485
      Completed
      Clinica de Oftalmologia Barraquer
      Barcelona, Spain, 08021
      Completed
      Institut Catala de Retina
      Barcelona, Spain, 08022
      Completed
      VOR - Hospital General de Catalunya
      Barcelona, Spain, 08195
      Completed
      Institut de la Macula
      Barcelona, Spain, 08022
      Completed
      Instituto Clinico Quirurgico de Oftalmologia
      Bilbao, Spain, 48010
      Completed
      Hospital La Arruzafa
      Córdoba, Spain, CP 14012
      Completed
      H.U. Puerta de Hierro-Majadahonda
      Majadahonda, Spain, 28222
      Completed
      Clinica Universidad de Navarra
      Pamplona, Spain, 31008
      Completed
      Instituto Oftalmologico Gomez-Ulla
      Santiago De Compostela, Spain, 15706
      Completed
      IMED Servicio Oftalmología
      Valencia, Spain, 46100
      Completed
      Rio Hortega University Hospital
      Valladolid, Spain, 47012
      Completed
      Hull University Teaching Hospitals NHS Trust
      Hull, United Kingdom, HU3 2JZ
      Completed
      Hospital Clínico Universitario "Lozano Blesa"
      Zaragoza, Spain, 50009
      Completed
      University of Bonn
      Bonn, Germany

      Frequently Asked Questions

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      In cancer clinical trials, a placebo is only used if there is no other treatment for that type of cancer. This helps compare an investigational treatment to the placebo. Placebos are rarely used in cancer trials because the best available treatment, called the “standard of care”, is usually given instead.

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