Study summary

This is a study that will test how an experimental drug (enfortumab vedotin) affects patients with cancer of the urinary system (urothelial cancer). This type of cancer includes cancer of the bladder, renal pelvis, ureter or urethra that has spread to nearby tissues or to other areas of the body.

This clinical trial will enroll patients who were previously treated with a kind of anticancer drug called an immune checkpoint inhibitor (CPI). Some CPIs have been approved for the treatment of urothelial cancer.

This study will test if the cancer shrinks with treatment. This study will also look at the side effects of the drug. A side effect is a response to a drug that is not part of the treatment effect.

Patients who sign up for this trial must also fall into one of these categories:

• Patients have already received treatment with platinum-containing chemotherapy

• Patients have never received platinum-containing treatment and are not eligible for treatment with cisplatin.

Additional Study Details

Phase
Phase 2
Product
enfortumab vedotin
Product
Enfortumab vedotin
Type
Interventional
Masking
None (Open Label)
Enrollment number
219
Show Additional Study Details

Get more information

Would you like more information about clinical trial sites that are recruiting participants for A Study of Enfortumab Vedotin for Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer? Contact us by filling out your information to the right and we’ll respond to you.

  • A caregiver
  • A healthcare provider
  • A parent
  • A patient
  • A patient advocate
  • Algeria
  • Argentina
  • Armenia
  • Australia
  • Austria
  • Belarus
  • Belgium
  • Bosnia And Herzegovina
  • Brazil
  • Bulgaria
  • Canada
  • Chile
  • China
  • Colombia
  • Croatia
  • Czech Republic
  • Denmark
  • Dominican Republic
  • Egypt
  • Estonia
  • Finland
  • Former Serbia and Montenegro
  • France
  • Georgia
  • Germany
  • Greece
  • Guatemala
  • Hong Kong
  • Hungary
  • Iceland
  • India
  • Indonesia
  • Ireland
  • Israel
  • Italy
  • Japan
  • Jordan
  • Kazakhstan
  • Latvia
  • Lebanon
  • Lithuania
  • Macedonia
  • Malaysia
  • Mexico
  • Montenegro
  • Morocco
  • Netherlands
  • New Zealand
  • Norway
  • Panama
  • Peru
  • Philippines
  • Poland
  • Portugal
  • Puerto Rico
  • Republic of Korea
  • Republic of Moldova
  • Romania
  • Russian Federation
  • Saudi Arabia
  • Serbia
  • Singapore
  • Slovakia
  • Slovenia
  • South Africa
  • Spain
  • Sweden
  • Switzerland
  • Taiwan, Province of China
  • Thailand
  • Turkey
  • Ukraine
  • United Kingdom
  • United States
  • Vietnam

By clicking ["Continue/Submit"], you agree that Astellas may contact you by email with information to help you connect with clinical trial sites. While we can connect you to clinical trial sites, we cannot answer questions about any investigational therapy through email. Your consent to receiving emails is not a requirement to participate in a clinical trial or study. For more information, including how to unsubscribe at any time, see our Privacy Notice & Cookies Policy.

    Locations

    Contact Us
    Contact Us
    Completed
    James Cancer Hospital / Ohio State University
    Columbus, OH, United States, 43210
    Completed
    Site KR82005
    Daejeon, Republic of Korea
    Completed
    Site DE49004
    Muenster, Germany
    Active, not recruiting
    New York University (NYU) Cancer Institute
    New York, NY, United States, 10016
    Completed
    Site JP81011
    Fukuoka, Fukuoka, Japan
    Completed
    Site JP81005
    Chiba, Chiba, Japan
    Active, not recruiting
    James P. Wilmot Cancer Center / University of Rochester Medical Center
    Rochester, NY, United States, 14642
    Completed
    Vanderbilt University Medical Center
    Nashville, TN, United States, 37204
    Completed
    Massachusetts General Hospital
    Boston, MA, United States, 02114
    Completed
    Kaiser Permanente San Leandro
    San Leandro, CA, United States, 94577
    Active, not recruiting
    Site JP81002
    Morioka, Iwate, Japan
    Active, not recruiting
    H. Lee Moffitt Cancer Center & Research Institute
    Tampa, FL, United States, 33612
    Completed
    Thomas Jefferson University
    Philadelphia, PA, United States, 19107
    Completed
    Arizona Oncology Associates, PC - HOPE
    Tucson, AZ, United States, 85710
    Active, not recruiting
    Augusta University
    Augusta, GA, United States, 30912
    Completed
    Site JP81010
    Tokushima, Tokushima, Japan
    Completed
    Site JP81006
    Shinjuku-ku, Tokyo, Japan
    Active, not recruiting
    Yale Cancer Center
    New Haven, CT, United States, 06520
    Completed
    Arizona Oncology Associates, PC - HAL
    Goodyear, AZ, United States, 85395
    Completed
    Site JP81007
    Osaka, Osaka, Japan
    Completed
    University of California Irvine - Newport
    Orange, CA, United States, 92868
    Completed
    Site NL31001
    Amsterdam, Netherlands
    Completed
    Site DE49001
    Tübingen, Germany
    Completed
    Kaiser Permanente Sacramento
    Sacramento, CA, United States, 95825
    Active, not recruiting
    Site ES34004
    Sevilla, Spain
    Active, not recruiting
    Site FR33001
    Villejuif-Cedex-France, France
    Completed
    Site ES34002
    Barcelona, Spain
    Active, not recruiting
    Keck Medical Center / Newport Beach
    Newport Beach, CA, United States, 92663
    Completed
    Mount Sinai Medical Center
    New York, NY, United States, 10029
    Completed
    Texas Oncology - Baylor Sammons Cancer Center
    Dallas, TX, United States, 75246
    Completed
    Kaiser Permanente Walnut Creek
    Walnut Creek, CA, United States, 94596
    Active, not recruiting
    Site JP81009
    Ube, Yamaguchi, Japan
    Active, not recruiting
    Keck Medical Center / University of Southern California
    Los Angeles, CA, United States, 90033
    Completed
    Site JP81012
    Fukuoka, Fukuoka, Japan
    Completed
    Site JP81003
    Nigata, Nigata, Japan
    Completed
    Chao Family Comprehensive Cancer Center University of California Irvine
    Orange, CA, United States, 92868
    Completed
    Kaiser Permanente San Jose
    San Jose, CA, United States, 95119
    Active, not recruiting
    Site ES34003
    Santander, Spain
    Completed
    Alaska Urological Institute
    Anchorage, AK, United States, 99503
    Completed
    Kaiser Permanente Oakland
    Oakland, CA, United States, 94611
    Completed
    Kaiser Permanente San Francisco
    San Francisco, CA, United States, 94115
    Active, not recruiting
    Site JP81004
    Tsukuba, Ibaraki, Japan
    Completed
    Texas Oncology - Austin Central
    Austin, TX, United States, 78731
    Completed
    Duke University Medical Center
    Durham, NC, United States, 27710
    Active, not recruiting
    Seattle Cancer Care Alliance / University of Washington
    Seattle, WA, United States, 98109-1023
    Completed
    Comprehensive Cancer Centers of Nevada
    Las Vegas, NV, United States, 89169
    Completed
    Kaiser Permanente Roseville
    Roseville, CA, United States, 95661
    Completed
    Karmanos Cancer Institute / Wayne State University
    Detroit, MI, United States, 48201
    Active, not recruiting
    Site IT39001
    Milano, Italy
    Active, not recruiting
    Site KR82001
    Seoul, Republic of Korea
    Completed
    Kaiser Permanente Medical Center Northern California
    Vallejo, CA, United States, 94589
    Active, not recruiting
    Site IT39003
    Terni, Italy
    Completed
    Kaiser Permanente Santa Clara
    Santa Clara, CA, United States, 95051
    Completed
    Virginia Cancer Specialists, PC
    Fairfax, VA, United States, 22031
    Completed
    Site JP81001
    Hirosaki, Aomori, Japan
    Completed
    Houston Methodist Cancer Center
    Houston, TX, United States, 77030
    Completed
    Kaiser Permanente South San Francisco
    South San Francisco, CA, United States, 94080
    Active, not recruiting
    Site KR82004
    Seoul, Republic of Korea
    Completed
    Cleveland Clinic
    Cleveland, OH, United States, 44195
    Completed
    Rocky Mountain Cancer Centers - Aurora
    Aurora, CO, United States, 80012
    Completed
    Site KR82002
    Seoul, Republic of Korea
    Completed
    Virginia Oncology Associates
    Norfolk, VA, United States, 23502
    Active, not recruiting
    Dana Farber Cancer Institute
    Boston, MA, United States, 02215
    Completed
    Site KR82003
    Seongnam-si, Republic of Korea
    Completed
    Site JP81008
    Osakasayama, Osaka, Japan
    Active, not recruiting
    Site ES34005
    Barcelona, Spain
    Completed
    Mayo Clinic Arizona
    Phoenix, Arizona, United States, 85054
    Active, not recruiting
    University of Chicago Medical Center
    Chicago, Illinois, United States, 60637-1470
    Completed
    Johns Hopkins Medical Center
    Baltimore, Maryland, United States, 21231
    Completed
    University of Virginia
    Charlottesville, Virginia, United States, 22903
    Active, not recruiting
    Washington University in St Louis
    St. Louis, Missouri, United States, 63110
    Completed
    University of California Davis
    Sacramento, California, United States, 95817
    Active, not recruiting
    Memorial Sloan Kettering Cancer Center
    New York, New York, United States, 10065
    Completed
    Maryland Oncology Hematology, P.A.
    Rockville, Maryland, United States, 20850
    Completed
    Ocala Oncology Center
    Ocala, Florida, United States, 34474
    Completed
    Northwest Cancer Specialists, P.C.
    Tigard, OREGON, United States, 97223
    Completed
    New York Oncology Hematology, P.C.
    Albany, New York, United States, 12208
    Active, not recruiting
    Columbia University Medical Center
    New York, New York, United States, 10032
    Active, not recruiting
    University of Pittsburgh Medical Center (UPMC)/Hillman Cancer Center
    Pittsburgh, Pennsylvania, United States, 15232
    Completed
    Prisma Health
    Greenville, South Carolina, United States, 29615
    Completed
    Norton Cancer Institute, St. Matthews Campus
    Louisville, Kentucky, United States, 40207

    Frequently Asked Questions

    Are clinical trials only for people with advanced cancer?

    While some clinical trials may focus on more advanced cancers, many trials are open to patients at various stages of their cancer. Each study has rules about who can take part. For example, only patients in a certain age group or those who have a certain type of tumor may be able to join.

    Will I have to stop my current treatment to participate in a clinical trial?

    Sometimes researchers want participants to keep taking their current treatments during a clinical trial. Other times, you may need to stop your current treatments for a while. If the investigational treatment doesn't work, you can usually go back to your original treatment plan.

    Should I be worried about getting a placebo?

    In cancer clinical trials, a placebo is only used if there is no other treatment for that type of cancer. This helps compare an investigational treatment to the placebo. Placebos are rarely used in cancer trials because the best available treatment, called the “standard of care”, is usually given instead.

    Do I need a referral from my doctor to take part in a study?

    Your doctor may not know about all the opportunities for clinical trials that are available to you. Talk to your doctor or other medical provider about clinical trial information that you find. They can help you decide if a clinical trial is right for you. If you do not find any options on this website, we recommend you visit an online public registry website like clinicaltrials.gov to see a wide variety of available clinical trials.

    Explore More

    1

    What are clinical trials?

    2

    Why are Clinical Trials Important?

    3

    Why Participate in a Clinical Trial?