Study summary

This is a study that will test how an experimental drug (enfortumab vedotin) affects patients with cancer of the urinary system (urothelial cancer). This type of cancer includes cancer of the bladder, renal pelvis, ureter or urethra that has spread to nearby tissues or to other areas of the body.

This clinical trial will enroll patients who were previously treated with a kind of anticancer drug called an immune checkpoint inhibitor (CPI). Some CPIs have been approved for the treatment of urothelial cancer.

This study will test if the cancer shrinks with treatment. This study will also look at the side effects of the drug. A side effect is a response to a drug that is not part of the treatment effect.

Patients who sign up for this trial must also fall into one of these categories:

• Patients have already received treatment with platinum-containing chemotherapy

• Patients have never received platinum-containing treatment and are not eligible for treatment with cisplatin.

Additional Study Details

Phase
Phase 2
Product
  • Enfortumab vedotin
  • Type
    Interventional
    Masking
    None (Open Label)
    Enrollment number
    219
    Show Additional Study Details

    Get more information

    Would you like more information about clinical trial sites that are recruiting participants for A Study of Enfortumab Vedotin for Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer? Contact us by filling out your information to the right and we’ll respond to you.

    • A patient
    • A caregiver
    • A parent
    • A healthcare provider
    • A patient advocate
    • Algeria
    • Argentina
    • Armenia
    • Australia
    • Austria
    • Belarus
    • Belgium
    • Bosnia And Herzegovina
    • Brazil
    • Bulgaria
    • Canada
    • Chile
    • China
    • Colombia
    • Croatia
    • Czech Republic
    • Denmark
    • Dominican Republic
    • Egypt
    • Estonia
    • Finland
    • Former Serbia and Montenegro
    • France
    • Georgia
    • Germany
    • Greece
    • Guatemala
    • Hong Kong
    • Hungary
    • Iceland
    • India
    • Indonesia
    • Ireland
    • Israel
    • Italy
    • Japan
    • Jordan
    • Kazakhstan
    • Latvia
    • Lebanon
    • Lithuania
    • Macedonia
    • Malaysia
    • Mexico
    • Montenegro
    • Morocco
    • Netherlands
    • New Zealand
    • Norway
    • Panama
    • Peru
    • Philippines
    • Poland
    • Portugal
    • Puerto Rico
    • Republic of Korea
    • Republic of Moldova
    • Romania
    • Russian Federation
    • Saudi Arabia
    • Serbia
    • Singapore
    • Slovakia
    • Slovenia
    • South Africa
    • Spain
    • Sweden
    • Switzerland
    • Taiwan, Province of China
    • Thailand
    • Turkey
    • Ukraine
    • United Kingdom
    • United States
    • Vietnam

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      Locations

      Contact Us
      Contact Us
      Completed
      James Cancer Hospital / Ohio State University
      Columbus, OH, United States, 43210
      Completed
      Site KR82005
      Daejeon, Republic of Korea
      Completed
      Site DE49004
      Muenster, Germany
      Active, not recruiting
      New York University (NYU) Cancer Institute
      New York, NY, United States, 10016
      Completed
      Site JP81011
      Fukuoka, Fukuoka, Japan
      Completed
      Site JP81005
      Chiba, Chiba, Japan
      Active, not recruiting
      James P. Wilmot Cancer Center / University of Rochester Medical Center
      Rochester, NY, United States, 14642
      Completed
      Vanderbilt University Medical Center
      Nashville, TN, United States, 37204
      Completed
      Massachusetts General Hospital
      Boston, MA, United States, 02114
      Completed
      Kaiser Permanente San Leandro
      San Leandro, CA, United States, 94577
      Active, not recruiting
      Site JP81002
      Morioka, Iwate, Japan
      Active, not recruiting
      H. Lee Moffitt Cancer Center & Research Institute
      Tampa, FL, United States, 33612
      Completed
      Thomas Jefferson University
      Philadelphia, PA, United States, 19107
      Completed
      Arizona Oncology Associates, PC - HOPE
      Tucson, AZ, United States, 85710
      Active, not recruiting
      Augusta University
      Augusta, GA, United States, 30912
      Completed
      Site JP81010
      Tokushima, Tokushima, Japan
      Completed
      Site JP81006
      Shinjuku-ku, Tokyo, Japan
      Active, not recruiting
      Yale Cancer Center
      New Haven, CT, United States, 06520
      Completed
      Arizona Oncology Associates, PC - HAL
      Goodyear, AZ, United States, 85395
      Completed
      Site JP81007
      Osaka, Osaka, Japan
      Completed
      University of California Irvine - Newport
      Orange, CA, United States, 92868
      Completed
      Site NL31001
      Amsterdam, Netherlands
      Completed
      Site DE49001
      Tübingen, Germany
      Completed
      Kaiser Permanente Sacramento
      Sacramento, CA, United States, 95825
      Active, not recruiting
      Site ES34004
      Sevilla, Spain
      Active, not recruiting
      Site FR33001
      Villejuif-Cedex-France, France
      Completed
      Site ES34002
      Barcelona, Spain
      Active, not recruiting
      Keck Medical Center / Newport Beach
      Newport Beach, CA, United States, 92663
      Completed
      Mount Sinai Medical Center
      New York, NY, United States, 10029
      Completed
      Texas Oncology - Baylor Sammons Cancer Center
      Dallas, TX, United States, 75246
      Completed
      Kaiser Permanente Walnut Creek
      Walnut Creek, CA, United States, 94596
      Active, not recruiting
      Site JP81009
      Ube, Yamaguchi, Japan
      Active, not recruiting
      Keck Medical Center / University of Southern California
      Los Angeles, CA, United States, 90033
      Completed
      Site JP81012
      Fukuoka, Fukuoka, Japan
      Completed
      Site JP81003
      Nigata, Nigata, Japan
      Completed
      Chao Family Comprehensive Cancer Center University of California Irvine
      Orange, CA, United States, 92868
      Completed
      Kaiser Permanente San Jose
      San Jose, CA, United States, 95119
      Active, not recruiting
      Site ES34003
      Santander, Spain
      Completed
      Alaska Urological Institute
      Anchorage, AK, United States, 99503
      Completed
      Kaiser Permanente Oakland
      Oakland, CA, United States, 94611
      Completed
      Kaiser Permanente San Francisco
      San Francisco, CA, United States, 94115
      Active, not recruiting
      Site JP81004
      Tsukuba, Ibaraki, Japan
      Completed
      Texas Oncology - Austin Central
      Austin, TX, United States, 78731
      Completed
      Duke University Medical Center
      Durham, NC, United States, 27710
      Active, not recruiting
      Seattle Cancer Care Alliance / University of Washington
      Seattle, WA, United States, 98109-1023
      Completed
      Comprehensive Cancer Centers of Nevada
      Las Vegas, NV, United States, 89169
      Completed
      Kaiser Permanente Roseville
      Roseville, CA, United States, 95661
      Completed
      Karmanos Cancer Institute / Wayne State University
      Detroit, MI, United States, 48201
      Active, not recruiting
      Site IT39001
      Milano, Italy
      Active, not recruiting
      Site KR82001
      Seoul, Republic of Korea
      Completed
      Kaiser Permanente Medical Center Northern California
      Vallejo, CA, United States, 94589
      Active, not recruiting
      Site IT39003
      Terni, Italy
      Completed
      Kaiser Permanente Santa Clara
      Santa Clara, CA, United States, 95051
      Completed
      Virginia Cancer Specialists, PC
      Fairfax, VA, United States, 22031
      Completed
      Site JP81001
      Hirosaki, Aomori, Japan
      Completed
      Houston Methodist Cancer Center
      Houston, TX, United States, 77030
      Completed
      Kaiser Permanente South San Francisco
      South San Francisco, CA, United States, 94080
      Active, not recruiting
      Site KR82004
      Seoul, Republic of Korea
      Completed
      Cleveland Clinic
      Cleveland, OH, United States, 44195
      Completed
      Rocky Mountain Cancer Centers - Aurora
      Aurora, CO, United States, 80012
      Completed
      Site KR82002
      Seoul, Republic of Korea
      Completed
      Virginia Oncology Associates
      Norfolk, VA, United States, 23502
      Active, not recruiting
      Dana Farber Cancer Institute
      Boston, MA, United States, 02215
      Completed
      Site KR82003
      Seongnam-si, Republic of Korea
      Completed
      Site JP81008
      Osakasayama, Osaka, Japan
      Active, not recruiting
      Site ES34005
      Barcelona, Spain
      Completed
      Mayo Clinic Arizona
      Phoenix, Arizona, United States, 85054
      Active, not recruiting
      University of Chicago Medical Center
      Chicago, Illinois, United States, 60637-1470
      Completed
      Johns Hopkins Medical Center
      Baltimore, Maryland, United States, 21231
      Completed
      University of Virginia
      Charlottesville, Virginia, United States, 22903
      Active, not recruiting
      Washington University in St Louis
      St. Louis, Missouri, United States, 63110
      Completed
      University of California Davis
      Sacramento, California, United States, 95817
      Active, not recruiting
      Memorial Sloan Kettering Cancer Center
      New York, New York, United States, 10065
      Completed
      Maryland Oncology Hematology, P.A.
      Rockville, Maryland, United States, 20850
      Completed
      Ocala Oncology Center
      Ocala, Florida, United States, 34474
      Completed
      Northwest Cancer Specialists, P.C.
      Tigard, OREGON, United States, 97223
      Completed
      New York Oncology Hematology, P.C.
      Albany, New York, United States, 12208
      Active, not recruiting
      Columbia University Medical Center
      New York, New York, United States, 10032
      Active, not recruiting
      University of Pittsburgh Medical Center (UPMC)/Hillman Cancer Center
      Pittsburgh, Pennsylvania, United States, 15232
      Completed
      Prisma Health
      Greenville, South Carolina, United States, 29615
      Completed
      Norton Cancer Institute, St. Matthews Campus
      Louisville, Kentucky, United States, 40207

      Frequently Asked Questions

      Are clinical trials only for people with advanced cancer?

      While some clinical trials may focus on more advanced cancers, many trials are open to patients at various stages of their cancer. Each study has rules about who can take part. For example, only patients in a certain age group or those who have a certain type of tumor may be able to join.

      Will I have to stop my current treatment to participate in a clinical trial?

      Sometimes researchers want participants to keep taking their current treatments during a clinical trial. Other times, you may need to stop your current treatments for a while. If the investigational treatment doesn't work, you can usually go back to your original treatment plan.

      Should I be worried about getting a placebo?

      In cancer clinical trials, a placebo is only used if there is no other treatment for that type of cancer. This helps compare an investigational treatment to the placebo. Placebos are rarely used in cancer trials because the best available treatment, called the “standard of care”, is usually given instead.

      Do I need a referral from my doctor to take part in a study?

      Your doctor may not know about all the opportunities for clinical trials that are available to you. Talk to your doctor or other medical provider about clinical trial information that you find. They can help you decide if a clinical trial is right for you. If you do not find any options on this website, we recommend you visit an online public registry website like clinicaltrials.gov to see a wide variety of available clinical trials.

      Explore More

      1

      What are clinical trials?

      2

      Why are Clinical Trials Important?

      3

      Why Participate in a Clinical Trial?