Study summary

This study will test an experimental drug (enfortumab vedotin) alone and with different combinations of anticancer therapies. Pembrolizumab is an immune checkpoint inhibitor (CPI) that is used to treat patients with cancer of the urinary system (urothelial cancer). This type of cancer includes cancer of the bladder, renal pelvis, ureter or urethra. Some parts of the study will look at locally advanced or metastatic urothelial cancer (la/mUC), which means the cancer has spread to nearby tissues or to other areas of the body. Other parts of the study will look at muscle-invasive bladder cancer (MIBC), which is cancer at an earlier stage that has spread into the muscle wall of the bladder. This study will look at the side effects of enfortumab vedotin alone and with other anticancer therapies. A side effect is a response to a drug that is not part of the treatment effect. This study will also test if the cancer shrinks with the different treatment combinations.

Additional Study Details

Phase
Phase 1/Phase 2
Product
  • enfortumab vedotin (EV)
  • pembrolizumab
  • cisplatin
  • carboplatin
  • gemcitabine
  • Type
    Interventional
    Masking
    None (Open Label)
    Enrollment number
    348
    Show Additional Study Details

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    Would you like more information about clinical trial sites that are recruiting participants for A Study of Enfortumab Vedotin Alone or With Other Therapies for Treatment of Urothelial Cancer? Contact us by filling out your information to the right and we’ll respond to you.

    • A patient
    • A caregiver
    • A parent
    • A healthcare provider
    • A patient advocate
    • Algeria
    • Argentina
    • Armenia
    • Australia
    • Austria
    • Belarus
    • Belgium
    • Bosnia And Herzegovina
    • Brazil
    • Bulgaria
    • Canada
    • Chile
    • China
    • Colombia
    • Croatia
    • Czech Republic
    • Denmark
    • Dominican Republic
    • Egypt
    • Estonia
    • Finland
    • Former Serbia and Montenegro
    • France
    • Georgia
    • Germany
    • Greece
    • Guatemala
    • Hong Kong
    • Hungary
    • Iceland
    • India
    • Indonesia
    • Ireland
    • Israel
    • Italy
    • Japan
    • Jordan
    • Kazakhstan
    • Latvia
    • Lebanon
    • Lithuania
    • Macedonia
    • Malaysia
    • Mexico
    • Montenegro
    • Morocco
    • Netherlands
    • New Zealand
    • Norway
    • Panama
    • Peru
    • Philippines
    • Poland
    • Portugal
    • Puerto Rico
    • Republic of Korea
    • Republic of Moldova
    • Romania
    • Russian Federation
    • Saudi Arabia
    • Serbia
    • Singapore
    • Slovakia
    • Slovenia
    • South Africa
    • Spain
    • Sweden
    • Switzerland
    • Taiwan, Province of China
    • Thailand
    • Turkey
    • Ukraine
    • United Kingdom
    • United States
    • Vietnam

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      Locations

      Contact Us
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      Recruiting
      University of Virginia
      Charlottesville, VA, United States, 22903
      Recruiting
      Medical College of Wisconsin (Milwaukee)
      Milwaukee, WI, United States, 53226
      Recruiting
      Winship Cancer Institute / Emory University School of Medicine
      Atlanta, GA, United States, 30322
      Recruiting
      Nebraska Hematology Oncology P.C.
      Lincoln, NE, United States, 68506
      Recruiting
      Gabrail Cancer Center Research, LLC
      Canton, OH, United States, 44718
      Recruiting
      Roswell Park Cancer Institute
      Buffalo, NY, United States, 14263
      Recruiting
      Weill Cornell Medical College
      New York, NY, United States, 10065
      Recruiting
      University of Miami
      Miami, FL, United States, 33136
      Recruiting
      Highlands Oncology Group
      Fayetteville, AR, United States, 72703
      Recruiting
      Levine Cancer Institute
      Charlotte, NC, United States, 28204
      Recruiting
      Henry Ford Health System
      Detroit, MI, United States, 48202
      Recruiting
      University of Chicago Medical Center
      Chicago, IL, United States, 60637-1470
      Recruiting
      University of Minnesota
      Minneapolis, MN, United States, 55455
      Recruiting
      Kaiser Permanente Southern California
      Woodland Hills, CA, United States, 91367
      Recruiting
      Medical University of South Carolina/Hollings Cancer Center
      Charleston, SC, United States, 29425
      Recruiting
      Arizona Oncology Associates, PC - HOPE
      Tucson, AZ, United States, 85710
      Recruiting
      University of Kansas Cancer Center
      Westwood, KS, United States, 66205
      Recruiting
      Tulane University Hospital and Clinic
      New Orleans, LA, United States, 70112
      Recruiting
      Stanford Cancer Center / Blood & Marrow Transplant Program
      Stanford, CA, United States, 94305
      Recruiting
      Cardinal Bernardin Cancer Center / Loyola University Medical Center
      Maywood, IL, United States, 60153
      Recruiting
      Yale Cancer Center
      New Haven, CT, United States, 06520
      Recruiting
      Rocky Mountain Cancer Centers - Aurora
      Aurora, CO, United States, 80012
      Recruiting
      University of California at San Francisco
      San Francisco, CA, United States, 94134
      Recruiting
      Memorial Sloan Kettering Cancer Center
      New York, NY, United States, 10087-9049
      Recruiting
      New York University (NYU) Cancer Institute
      New York, NY, United States, 10016
      Recruiting
      Allegheny General Hospital
      Pittsburgh, PA, United States, 15212
      Recruiting
      Piedmont Cancer Institute
      Atlanta, GA, United States, 30309
      Recruiting
      Banner MD Anderson Cancer Center
      Gilbert, AZ, United States, 85234
      Recruiting
      Hackensack University Medical Center
      Hackensack, NJ, United States, 07601
      Recruiting
      University of Colorado Hospital / University of Colorado
      Aurora, CO, United States, 80045-0510
      Recruiting
      University of Michigan Comprehensive Cancer Center
      Ann Arbor, MI, United States, 48109
      Recruiting
      University of California Irvine - Newport
      Orange, CA, United States, 92868
      Recruiting
      Carolina Urologic Research Center
      Myrtle Beach, SC, United States, 29572
      Recruiting
      UNC Lineberger Comprehensive Cancer Center / University of North Carolina
      Chapel Hill, NC, United States, 27599
      Recruiting
      University of Texas Health Science Center at San Antonio
      San Antonio, TX, United States, 78229
      Completed
      Alaska Urological Institute
      Anchorage, AK, United States, 99503
      Recruiting
      UC San Diego / Moores Cancer Center
      La Jolla, CA, United States, 92093
      Recruiting
      Saint Joseph Heritage Medical Group
      Santa Rosa, CA, United States, 95403
      Recruiting
      University of New Mexico Cancer Center
      Albuquerque, NM, United States, 87106
      Recruiting
      Decatur Memorial Hospital - Illinois
      Decatur, IL, United States, 62526
      Recruiting
      Case Western Reserve University / University Hospitals Case Medical Center
      Cleveland, OH, United States, 44106
      Recruiting
      University of California, Davis Comprehensive Cancer Center
      Sacramento, CA, United States, 95817
      Recruiting
      Penn State Milton S. Hershey Medical Center
      Hershey, PA, United States, 17033
      Completed
      Utah Cancer Specialists
      Salt Lake City, UT, United States, 84106
      Recruiting
      Northwestern Medicine Cancer Center Delnor
      Geneva, IL, United States, 60134
      Recruiting
      McLaren Greater Lansing Hospital
      Lansing, MI, United States, 48910
      Recruiting
      OptumCare Cancer Center
      Las Vegas, NV, United States, 89102
      Recruiting
      University of Mississippi Medical Center
      Jackson, MS, United States, 39213
      Recruiting
      Mayo Clinic Arizona
      Phoenix, AZ, United States, 85054
      Completed
      University of Rochester Medical Center
      Rochester, NY, United States, 14642
      Recruiting
      Fox Chase Cancer Center
      Philadelphia, PA, United States, 19111
      Recruiting
      Mayo Clinic Florida
      Jacksonville, FL, United States, 32224
      Recruiting
      Georgetown University Medical Center
      Washington, DC, United States, 20007
      Recruiting
      Medical Oncology Associates
      Spokane, WA, United States, 99208
      Recruiting
      Ochsner Clinic Foundation
      New Orleans, LA, United States, 70121
      Recruiting
      Boca Raton Regional Hospital / Lynn Cancer Institute
      Boca Raton, FL, United States, 33486
      Recruiting
      Washington University School of Medicine - Siteman Cancer Center
      Saint Louis, MO, United States, 63110
      Recruiting
      Tower Hematology Oncology Medical Group
      Beverly Hills, CA, United States, 90211
      Recruiting
      Southcoast Centers for Cancer Care - Fairhaven Site
      Fairhaven, MA, United States, 02719
      Recruiting
      Northwestern Medicine Cancer Center - Kishwaukee / Kishwaukee Cancer Center
      DeKalb, IL, United States, 60115
      Recruiting
      Northwestern Medicine Cancer Center - Warrenville / Central DuPage Hospital - Cancer Care
      Warrenville, IL, United States, 60555
      Recruiting
      Memorial Sloan Kettering Cancer Center - Bergen
      Montvale, NJ, United States, 07645
      Recruiting
      Memorial Sloan Kettering Cancer Center - Commack
      Commack, NY, United States, 11725
      Recruiting
      Memorial Sloan Kettering Cancer Center - Monmouth
      Middletown, NJ, United States, 07748
      Recruiting
      Memorial Sloan Kettering Cancer Center - Nassau
      Uniondale, NY, United States, 11553
      Recruiting
      Memorial Sloan Kettering Cancer Center - Westchester
      West Harrison, NY, United States, 10604
      Recruiting
      Memorial Sloan Kettering Cancer Center - Basking Ridge
      Basking Ridge, NJ, United States, 07920
      Recruiting
      Sarah Cannon Research Institute
      Chattanooga, TN, United States, 37404
      Recruiting
      Tennessee Oncology / Sarah Cannon Research Institute
      Nashville, TN, United States, 37203
      Recruiting
      Toledo Clinic Cancer Center
      Toledo, OH, United States, 43623
      Recruiting
      Eastern CT Hematology and Oncology Associates
      Norwich, CT, United States, 06360
      Completed
      Saint Francis Hospital Cancer Center
      Greenville, SC, United States, 29607
      Recruiting
      Vidant Medical Center
      Greenville, NC, United States, 27834
      Recruiting
      Texas Oncology - Fort Worth Cancer Center
      Fort Worth, TX, United States, 76104
      Recruiting
      Texas Oncology - Tyler
      Tyler, TX, United States, 75702
      Recruiting
      Site CA11005
      Montreal, Quebec, Canada, H3T1E2
      Recruiting
      CMOH Broomall
      Broomall, PA, United States, 19008
      Recruiting
      New York Oncology Hematology, P.C.
      Albany, NY, United States, 12206
      Recruiting
      NYU Winthrop Hospital
      Mineola, NY, United States, 11501
      Recruiting
      Site CA11002
      Sherbrooke, Quebec, Canada, J1H 5N4
      Recruiting
      Northwell Cancer Center / Monter Cancer Center
      Lake Success, NY, United States, 11042
      Recruiting
      Site CA11011
      Kingston, Ontario, Canada, K7L 2V7
      Recruiting
      Holy Cross Hospital - Michael and Dianne Bienes Comprehensive Cancer Center
      Fort Lauderdale, FL, United States, 33308
      Recruiting
      Maryland Oncology Hematology, P.A.
      Silver Spring, MD, United States, 20904
      Recruiting
      Site CA11013
      Montreal, Quebec, Canada, H4A3J1
      Recruiting
      Site CA11001
      Toronto, Ontario, Canada, M5G 2M9
      Recruiting
      Site CA11008
      East Brampton, Ontario, Canada, L6R 3J7
      Recruiting
      Duke University Medical Center
      Durham, NC, United States, 27710
      Recruiting
      Site FR33001
      Strasbourg, France, 67200
      Recruiting
      Site FR33002
      Nice Cedex, France, 06189
      Recruiting
      Site FR33003
      Lyon, France, 69008
      Recruiting
      Site FR33008
      Bordeaux, France, 33000
      Recruiting
      Site PR78701
      Rio Piedras, Puerto Rico, 00935
      Recruiting
      Virginia Oncology Associates - Norfolk
      Norfolk, VA, United States, 23502
      Recruiting
      Site FR33004
      Marseilles, France, 13273
      Completed
      Site FR33005
      Dijon, France, 21000
      Recruiting
      Site FR33006
      Pierre-Benite, France, 69310
      Recruiting
      Site FR33010
      Moselle, France, 54519
      Recruiting
      Site IT39002
      Terni, Italy, 05100
      Completed
      Site ES34001
      Madrid, Spain, 28034
      Completed
      Site ES34004
      Santander, Spain, 39008
      Completed
      Site ES34005
      Sabadell, Spain, 08208
      Recruiting
      Site ES34006
      Barcelona, Spain, 08041
      Completed
      Site ES34007
      Pamplona, Spain, 31008
      Recruiting
      Site ES34008
      Madrid, Spain, 28033
      Completed
      Site ES34012
      Madrid, Spain, 28041

      Frequently Asked Questions

      Are clinical trials only for people with advanced cancer?

      While some clinical trials may focus on more advanced cancers, many trials are open to patients at various stages of their cancer. Each study has rules about who can take part. For example, only patients in a certain age group or those who have a certain type of tumor may be able to join.

      Will I have to stop my current treatment to participate in a clinical trial?

      Sometimes researchers want participants to keep taking their current treatments during a clinical trial. Other times, you may need to stop your current treatments for a while. If the investigational treatment doesn't work, you can usually go back to your original treatment plan.

      Should I be worried about getting a placebo?

      In cancer clinical trials, a placebo is only used if there is no other treatment for that type of cancer. This helps compare an investigational treatment to the placebo. Placebos are rarely used in cancer trials because the best available treatment, called the “standard of care”, is usually given instead.

      Do I need a referral from my doctor to take part in a study?

      Your doctor may not know about all the opportunities for clinical trials that are available to you. Talk to your doctor or other medical provider about clinical trial information that you find. They can help you decide if a clinical trial is right for you. If you do not find any options on this website, we recommend you visit an online public registry website like clinicaltrials.gov to see a wide variety of available clinical trials.

      Explore More

      1

      What are clinical trials?

      2

      Why are Clinical Trials Important?

      3

      Why Participate in a Clinical Trial?