Study Details
Enfortumab vedotin and pembrolizumab vs. chemotherapy alone in untreated locally advanced or metastatic urothelial cancer
Clinicaltrials.gov ID
Astellas Study ID
SGN22E-003
EudraCT ID
2019-004542-15
Condition
Bladder Cancer
Phase
Phase 3
Age
18 Years - N/A
Sex
Female & Male
Product
enfortumab vedotin
Type
Interventional
Trial Dates
Mar 2020 - Sep 2027
Masking
None (Open Label)
Enrollment number
990
An open-label, randomized, controlled phase 3 study of enfortumab vedotin in combination with pembrolizumab versus chemotherapy alone in previously untreated locally advanced or metastatic urothelial cancer
Study summary
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Locations
Maine Health Cancer Care
Biddeford, United States, 04046
Georgia Cancer Specialists / Northside Hospital Cancer Institute
Marietta, United States, 30060
Vidant Medical Center
Greenville, United States, 27834
Cancer Centers of Colorado - Denver
Denver, United States, 80218
Mount Sinai Medical Center
New York, United States, 10029
Johns Hopkins Medical Center
Baltimore, United States, 21231
Rocky Mountain Cancer Centers - Aurora
Aurora, United States, 80012
University of Colorado Hospital / University of Colorado
Aurora, United States, 80045
UT Health East Texas Hope Cancer Center
Tyler, United States, 75701
Winship Cancer Institute / Emory University School of Medicine
Atlanta, United States, 30322
Toledo Clinic Cancer Center
Toledo, United States, 43623
The Cleveland Clinic
Cleveland, United States, 44195
Arizona Oncology Associates PD - HOPE
Tucson, United States, 85710
Ironwood Cancer & Research Centers - Chandler
Chandler, United States, 85224
City of Hope National Medical Center
Duarte, United States, 91010
H. Lee Moffitt Cancer Center and Research Institute
Tampa, United States, 33612
Comprehensive Cancer Centers of Nevada
Las Vegas, United States, 89169
University of Virginia
Charlottesville, United States, 22908
Lombardi Cancer Center / Georgetown University Medical Center
Washington, United States, 20007
Louisiana State University/ East Jefferson General Hospital
Metairie, United States, 70006
West Cancer Center & Research Institute
Germantown, United States, 38138
New Mexico Cancer Center
Albuquerque, United States, 87109
University of Texas Southwestern Medical Center
Dallas, United States, 75390
Seattle Cancer Care Alliance / University of Washington
Seattle, United States, 98109
Saint Francis Hospital / Bon Secours - South Carolina
Greenville, United States, 29607
Hillman Cancer Center / University of Pittsburgh Medical Center
Pittsburgh, United States, 15232
University of California Irvine - Newport
Orange, United States, 92868
Huntsman Cancer Institute
Salt Lake City, United States, 84112
Memorial Sloan Kettering Cancer Center
New York, United States, 10065
Eastern CT Hematology and Oncology Associates
Norwich, United States, 06360
Providence St Joseph Medical Center
Burbank, United States, 91505
University of California Los Angeles Medical Center
Los Angeles, United States, 90095
Site CA11001
Montreal, Canada, H3T 1E2
Site CA11003
Edmonton, Canada, T6G 1Z2
Site ES34002
Madrid, Spain, 28034
Site ES34004
Manresa, Spain, 08243
Site ES34007
Sevilla, Spain, 41013
Site ES34010
Barcelona, Spain, 08035
Site ES34020
Pamplona, Spain, 31008
Site KR82008
Hwasun, Republic of Korea, 519-763
Site CA11009
London, Canada, N6A 5A5
Site AUS61006
South Australia, Australia, 5112
Site AUS61002
Macquarie Park, Australia, 2109
Site CA11008
Quebec, Canada, G1R 2J6
Site CA11011
Oshawa, Canada, L1G 2B9
Site ES34016
Sabadell, Spain, 08208
Site ES34017
Barcelona, Spain, 08003
Site ES34001
Barcelona, Spain, 08041
Site ES34012
Santander, Spain, 39008
Site CA11005
Toronto, Canada, M5G 2M9
Site CA11004
Calgary, Canada, T2N 4N2
Site CA11006
Vancouver, Canada, V5Z 4E6
Site CA11010
Montreal, Canada, H2X 0A9
Site AUS61004
Heidelberg, Australia, 3084
Site AUS61001
Douglas, Australia, 4814
Site FR33016
Lyon, France, 69373
Site RU70002
Omsk, Russian Federation, 644013
Site RU70010
Saint Petersburg, Russian Federation, 195271
Site RU70007
Saint Petersburg, Russian Federation, 197082
Site RU70005
Ufa, Russian Federation, 450000
Site RU70006
Leningradskaya oblast', Russian Federation, 188663
Site KR82001
Daejeon, Republic of Korea, 301-721
Site KR82002
Goyang-si, Republic of Korea, 10408
Site KR82003
Seoul, Republic of Korea, 03722
Site KR82004
Seongnam-si, Republic of Korea, 13605
Site KR82007
Seoul, Republic of Korea, 135-710
Site ES34013
Cordoba, Spain, 14004
Site CH41002
Bern, Switzerland, 3010
Site CH41001
Chur, Switzerland, 7000
Site CH41003
Winterthur, Switzerland, 8401
Site TW88607
Taichung, Taiwan, Province of China, 40447
Site TW88601
Taipei, Taiwan, Province of China, 11217
Site TW88604
Tainan, Taiwan, Province of China, 70403
Site TW88605
Taipei, Taiwan, Province of China, 10002
New York University (NYU) Cancer Institute
New York, United States, 10016
Site CA11002
Hamilton, Canada, L8V 1C3
Site NL31002
Amsterdam, Netherlands, 1066 CX
Site NL31004
Nieuwegein, Netherlands, 3435 CM
Site NL31006
Utrecht, Netherlands, 3584 CX
Site BE32001
Liege, Belgium, 4000
Site BE32002
Ghent, Belgium, 9000
Site BE32003
Brussels, Belgium, 1200
Site BE32006
Roeselare, Belgium, 8800
Site ES34019
Valencia, Spain, 46009
Site ES34021
Lugo, Spain, 27003
Site HU36001
Nyiregyhaza, Hungary, 4400
Site HU36002
Budapest, Hungary, 1122
Site IT39002
Terni, Italy, 05100
Site IT39006
Genova, Italy, 16132
Site DE49004
Tübingen, Germany, 72076
Site DE49007
Frankfurt am Main, Germany, 60488
Site DE49013
Bielefeld, Germany, 33611
Site AU61003
Box Hill, Australia, 3128
Site RU70003
Moscow, Russian Federation, 125284
Site RU70009
Saransk, Russian Federation, 430032
Site RU70013
Barnaul, Russian Federation, 656049
Site RU70014
Krasnoyarsk, Russian Federation, 660133
Site RU70016
Arkhangelsk, Russian Federation, 163045
Site JP81001
Koto-ku, Japan
Site JP81002
Bunkyo City, Japan
Site JP81003
Toyama, Japan
Site JP81004
Tsukuba, Japan
Site JP81006
Kawasaki-shi, Japan
Site KR82005
Seoul, Republic of Korea, 05505
Site KR82006
Seoul, Republic of Korea, 137-701
Site TW88606
Taichung, Taiwan, Province of China, 40705
Site JP81005
Okayama, Japan
Site RU70011
Moscow, Russian Federation, 123056
Site JP81009
Chiba, Japan
Site IT39001
Verona, Italy, 37134
Site NL31005
Amsterdam, Noord-Holland, Netherlands, 1066 CX
Site IT39004
Pisa, Italy, 56126
Yale Cancer Center
New Haven, United States, 06520
Site IT39005
Areezo, Italy, 52100
Site DK45001
Aalborg, Denmark, 9100
Site FR33011
Villejuif-Cedex-France, France, 94805
Site IT39008
Candiolo, Italy, 10060
Site NL31007
Leeuwarden, Netherlands, 8934 AD
Site UK44001
London, United Kingdom, EC1M 6BQ
Site UK44002
Preston, United Kingdom, PR2 9HT
Site CA11012
Toronto, Canada, M4N 3M5
Site ES34008
Barcelona, Spain, 08907
Site AU61005
South Brisbane, Australia, 4101
Site BE32007
Lueven, Belgium, 3000
Site DE49002
Munchen, Germany, 81675
Site DE49010
Ulm, Germany, 89081
Site DE49011
Essen, Germany, 45147
Site DE49012
Mannheim, Germany, 68167
Site ES34006
Barcelona, Spain, 08036
Site ES34009
Valencia, Spain, 46014
Site ES34015
Madrid, Spain, 28041
Site IT39003
Meldola, Italy, 47014
Site IT39007
Milano, Italy, 20141
Site IT39009
Cremona, Italy, 26100
Site IT39011
Torrette, Italy, 60126
Site JP81007
Sapporo, Japan
Site JP81008
Osaka, Japan
Site JP81010
Ube, Japan
Site JP81016
Osakasayama-Shi, Japan
Site JP81017
Kyoto, Japan
Site JP81018
Chiba, Japan
Site NL31001
Amsterdam, Netherlands, 1081 HV
Site NL31003
Rotterdam, Netherlands, 3075 EA
Site RU70012
Saint-Petersburg, Russian Federation, 197758
Site SG65002
Singapore, Singapore, 169610
Site TW88602
Kweishan, Taiwan, Province of China, 333
Site UK44006
Oxford, United Kingdom, OX3 7LE
Site DE49009
Herne, Germany, 44649
Site JP81011
Hirosaki, Japan
Site JP81019
Tokyo, Japan
Site RU70004
Moscow, Russian Federation, 105077
Site UK44005
Glasgow, United Kingdom, G12 0YN
Site JP81014
Tokushima, Japan
Site JP81013
Fukuoka, Japan
Site JP81012
Sendai-city, Japan
Site JP81015
Niigata, Japan
Site HU36005
Szolnok, Hungary, 5004
Site HU36006
Debrecen, Hungary, 4032
Site JP81020
Fukuoka, Japan
Site RU70008
St. Petersburg, Russian Federation, 197758
Site RU70015
Tyumen, Russian Federation, 625041
Site RU70020
Ivanovo, Russian Federation, 153040
Site SG65003
Singapore, Singapore, 308433
Site TR90001
Konya, Turkey, 42080
Site TR90002
Istanbul, Turkey, 81450
Site DE49005
Heidelberg, Germany, 69120
Site RU70017
Nizhniy Novgorod, Russian Federation, 603074
Site TR90009
Ankara, Turkey, 6230
Site UK44009
London, United Kingdom, W6 8RF
Site AR54002
San Miguel, Argentina, T400GTB
Site ES34018
Madrid, Spain, 28007
Site AR54008
Buenos Aire, Argentina, C1019ABS
Site RU70019
Pyatigorsk, Russian Federation, 357502
Site AR54006
La Rioja, Argentina, 5300
Site TW88603
Kaohsiung, Taiwan, Province of China, 83301
Site TH66001
Ratchathewi, Thailand, 10400
Site TH66002
HatYai, Thailand, 90110
Site TH66003
Bangkok, Thailand, 10400
Site TH66004
Bangkok, Thailand, 10330
Site TH66005
Chiang Mai, Thailand, 50200
Site TH66006
Krung Thep Maha Nakhon, Thailand, 10700
Site TH66007
Muang, Thailand, 40002
Site FR33013
Strasbourg, France, 67200
Site FR33014
Bordeaux, France, 33000
Site AR54001
Rosario, Argentina, 2000
Site CZ42001
Hradec Kralove, Czech Republic, 500 05
Site DE49014
Erlangen, Germany, 91054
Site DE49016
Düsseldorf, Germany, 40225
Site FR33003
Nice Cedex 2, France, 06189
Site HU36003
Budapest, Hungary, 1083
Site AR54012
Tucuman, Argentina, T4000IAK
Site AR54003
Viedma, Argentina, 8500
Site DK45003
Aarhus N, Denmark, 8200
Site IL97203
Beer Sheva, Israel, 84101
Site IL97211
Rehovot, Israel, 76100
Site IL97204
Tel Hashomer, Israel, 52621
Site IL97206
Jerusalem, Israel, 91120
Site IL97201
Haifa, Israel, 31096
Site IL97205
Zerifin, Israel, 70300
Site IL97208
Petach Tikva, Israel, 49414
Site SG65001
Singapore, Singapore, 119074
Site UK44003
Sheffield, United Kingdom, S10 2RX
Site TR90007
Ankara, Turkey, 6100
Site FR33017
TOURS Cedex 09, France, 37044
Site CH41004
Basel, Switzerland, 4031
Site CZ42005
Praha 4-Krc, Czech Republic, 140 59
Site DE49001
Lubeck, Germany, 23538
Site DE49008
Magdeburg, Germany, 39120
Site IL97202
Kfar Saba, Israel, 44281
Site IL97209
Holon, Israel, 58100
Site IL97210
Tel Aviv, Israel, 64239
Site FR33020
Pierre-Bénite, France, 69495
Site CZ42004
Olomouc, Czech Republic, 779 00
Site CZ42006
Brno, Czech Republic, 656 91
Site DE49003
Berlin, Germany, 10117
Site TR90003
Istanbul, Turkey, 34214
Site TR90008
Istanbul, Turkey, 34093
Site UK44010
Plymouth, United Kingdom, PL6 8DH
Site TR90005
Antalya, Turkey, 07059
Site TR90006
Malatya, Turkey, 44280
Site PL48002
Warszawa, Poland, 01-748
Site UK44008
Southampton, United Kingdom, SO16 6YD
Site CN86001
Beijing, China, 100036
Site AR54004
Mendoza, Argentina, M5500AYB
Site AR54005
Cordoba, Argentina, X5004FHP
Site AR54011
CABA, Argentina, C1426ANZ
Site DE49006
Jena, Germany, 07747
Site DE49015
Gottingen, Germany, 37099
Site TR90004
Edirne, Turkey, 22030
Site CN86004
Beijing, China, 100050
Site CN86005
Beijing, China, 100191
Site CN86017
Nanjing, China, 210008
Site IT39014
Milano, Italy, 20132
Site ES34003
Madrid, Spain, 28040
Site CN86013
Hangzhou, China, 310014
Site CN86015
Bengbu, China, 233000
Site CN86016
Changsha, China, 410013
Site CN86018
Hangzhou, China, 0571
Site CN86019
Tianjin, China, 453000
Site CN86003
Changchun, China, 130021
Site CN86007
Chongqing, China, 400038
Site CN86008
Wuhan City, China, 430030
Site CN86009
Beijing City, China, 100021
Site CN86011
Shenyang City, China, 110022
Site CN86014
Shanghai, China, 200040
Site CN86020
Gunagzhou, China, 510280
Site CN86023
Tianjin, China, 300052
Site CN86002
Guangzhou, China, 510120
Site CN86012
Nanjing, China, 210029
Site CN86027
Jinan, China, 250021
Site CN86029
Wenzhou, China, 325000
Site CN86026
Xuzhou, China, 221009
Site CN86030
Xicheng District, China, 100034
Site CN86022
Hangzhou, China, 310016
Site CN86021
Ningbo, China, 315016
Site CN86025
Hefei, China, 400030
Site CN86028
Fuzhou, China, 350005
Site CN86010
Chengdu, China, 610041
Site CN86024
Chongqing, China, 400030
Site CN86006
Changsha, China, 410013
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